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Teicoplanin

Synonyms: Teichomycin,Targocid,MDL-507

Teicoplanin (Teichomycin,Targocid,MDL-507) is a glycopeptide antibiotic, used to treat serious infections caused by Gram-positive bacteria.

Teicoplanin Chemical Structure

Teicoplanin Chemical Structure

CAS No. 61036-62-2

Purity & Quality Control

Teicoplanin Related Products

Biological Activity

Description Teicoplanin (Teichomycin,Targocid,MDL-507) is a glycopeptide antibiotic, used to treat serious infections caused by Gram-positive bacteria.
In vitro
In vitro

Teicoplanin is associated with small increases in the GI colonization by C. albicans. [1] The inhibitory action of Teicoplanin on proteoglycan polymerization but not on nucleic acid and protein synthesis indicates that the effect in the wall is due to the accumulation at this level of proteoglycan soluble precursors continuously produced by the cell. [2] Teicoplanin, at a concentration of 1 mg/mL, causes rapid lysis of exponential phase cells of Streptococcus faecalis. [3] Teicoplanin inhibits peptidoglycan synthesis in intact cells and in cell-free systems. Teicoplanin-induced lysis is dependent on the growth phase of B. pumilus at the time of addition of the antibiotic. Teicoplanin induces lysis after a longer lag phase with slowly growing Strep. jhecalis CCM 1875 and lysis is not very extensive. [4]
In Vivo
In vivo

Teicoplanin therapy increases the survival rate whereas G-CSF therapy does not in comparison to other groups in neutropenic mice. Teicoplanin and G-CSF combination therapy improves survival rate when compared with groups II, III, IV. [5]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03909698 Completed
Kidney Failure Chronic|Antibiotics|Hemodialysis
University Hospital Ghent|University Ghent
 September 15 2016 --
NCT03229135 Completed
Pneumonia Gram-Positive Bacterial
People''s Hospital of Zhengzhou University
 February 1 2015 --
NCT03177369 Completed
Teicoplanin-based Antimicrobial Therapy|Staphylococcus Aureus|Bone and Joint Infection
Hospices Civils de Lyon
 January 2015 --
NCT01324804 Unknown status
Coronary Heart Disease|Surgical Wound Infection
Medical University of Vienna
 November 2010 --
NCT00754273 Completed
Methicillin-resistant Staphylococcal Aureus Pneumonia
University of Kentucky|Pfizer
 September 2008 --

Chemical Information & Solubility

Molecular Weight 1709.39 Formula

C77H77N9O31Cl2·R
CAS No. 61036-62-2 SDF Download Teicoplanin SDF
Smiles CCCCCCCCCC(=O)NC1C(C(C(OC1OC2=C3C=C4C=C2OC5=C(C=C(C=C5)C(C6C(=O)NC(C7=C(C(=CC(=C7)O)OC8C(C(C(C(O8)CO)O)O)O)C9=C(C=CC(=C9)C(C(=O)N6)NC(=O)C4NC(=O)C1C2=CC(=CC(=C2)OC2=C(C=CC(=C2)C(C(=O)NC(CC2=CC(=C(O3)C=C2)Cl)C(=O)N1)N)O)O)O)C(=O)O)OC1C(C(C(C(O1)CO)O)O)NC(=O)C)Cl)CO)O)O
Storage (From the date of receipt)

In vitro
Batch:

Water : 100 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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