Home Neuronal Signaling Adrenergic Receptor agonist Tizanidine HCl For research use only.

Tizanidine HCl

Synonyms: DS 103-282

Tizanidine HCl (DS 103-282) is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons.

Tizanidine HCl Chemical Structure

Tizanidine HCl Chemical Structure

CAS No. 64461-82-1

Purity & Quality Control

Batch: S143701 Water]15 mg/mL]false]DMSO]10 mg/mL]false]Ethanol]Insoluble]false Purity: 99.87%
99.87

Tizanidine HCl Related Products

Signaling Pathway

Adrenergic Receptor Signaling Pathways

Adrenergic Receptor Signaling Pathway

Biological Activity

Description Tizanidine HCl (DS 103-282) is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons.
Targets
α2-adrenergic receptor [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01844674 Completed
Malignant Melanoma Neoplasms
Hoffmann-La Roche
 September 2 2013 Phase 1
NCT01839279 Completed
Spasticity
Acorda Therapeutics
 April 2013 Phase 2
NCT01405950 Terminated
Spasticity Due to Cerebral Palsy
Acorda Therapeutics|Syneos Health
 May 2011 Phase 1
NCT01065987 Completed
Healthy
Dr. Reddy''s Laboratories Limited
 September 2001 Phase 1

Chemical Information & Solubility

Molecular Weight 290.17 Formula

C9H8ClN5S.HCl
CAS No. 64461-82-1 SDF Download Tizanidine HCl SDF
Smiles C1CN=C(N1)NC2=C(C=CC3=NSN=C32)Cl.Cl
Storage (From the date of receipt)

In vitro
Batch:

Water : 15 mg/mL

DMSO : 10 mg/mL ( (34.46 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


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In vivo
Batch:

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In vivo Formulation Calculator

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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