Home Neuronal Signaling Adrenergic Receptor antagonist Sotalol HCl For research use only.

Sotalol HCl

Synonyms: MJ-1999

Sotalol(MJ-1999) is a non-selective beta blocker and a potassium channel blocker with an IC50 of 43 μM.

Sotalol HCl Chemical Structure

Sotalol HCl Chemical Structure

CAS No. 959-24-0

Purity & Quality Control

Sotalol HCl Related Products

Signaling Pathway

Adrenergic Receptor Signaling Pathways

Adrenergic Receptor Signaling Pathway

Biological Activity

Description Sotalol(MJ-1999) is a non-selective beta blocker and a potassium channel blocker with an IC50 of 43 μM.
Targets
β-adrenergic receptor [1] Potassium channel [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05247320 Completed
Atrial Arrhythmia
University of Utah|AltaThera Pharmaceuticals LLC
 February 4 2022 --
NCT03799536 Completed
Bioequivalence
Pharmtechnology LLC|National Anti-Doping Labaratory
 January 9 2019 Phase 1
NCT01338441 Completed
Cardiology: RR / QT
Ectycell SASU|Pierre and Marie Curie University|Institut National de la Santé Et de la Recherche Médicale France
 March 2011 Phase 1
NCT01097330 Terminated
Defibrillators Implantable|Tachycardia Ventricular
Population Health Research Institute|Abbott Medical Devices|Hamilton Health Sciences Corporation
 August 2010 Phase 3

Chemical Information & Solubility

Molecular Weight 308.82 Formula

C12H20N2O3S.HCl
CAS No. 959-24-0 SDF Download Sotalol HCl SDF
Smiles CC(C)NCC(C1=CC=C(C=C1)NS(=O)(=O)C)O.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 62 mg/mL ( (200.76 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 62 mg/mL

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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