Home Endocrinology & Hormones Estrogen/progestogen Receptor agonist MPA (Medroxyprogesterone acetate) For research use only.

MPA (Medroxyprogesterone acetate)

Synonyms: NSC-26386, Medroxyprogesterone 17-acetate, Farlutin

MPA (Medroxyprogesterone acetate) is a synthetic progestin and act as a potent progesterone receptor agonist, used to treat abnormal menstruation or irregular vaginal bleeding.

MPA (Medroxyprogesterone acetate) Chemical Structure

MPA (Medroxyprogesterone acetate) Chemical Structure

CAS No. 71-58-9

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MPA (Medroxyprogesterone acetate) Related Products

Signaling Pathway

Estrogen/progestogen Receptor Signaling Pathways

Estrogen/progestogen Receptor Signaling Pathway

Biological Activity

Description MPA (Medroxyprogesterone acetate) is a synthetic progestin and act as a potent progesterone receptor agonist, used to treat abnormal menstruation or irregular vaginal bleeding.
Targets
progestogen Receptor [1]
In vitro
In vitro

Medroxyprogesterone acetate (MPA) inhibits the enzyme 3-hydroxyste-roid dehydrogenase, involved in the reversible conversion between 5alpha-dihydroprogesterone (DHP) and 3alpha, 5alpha-tetrahydroprogesterone (THP), and therefore may affect the local actions of DHP and THP in the brain. [1]

Medroxyprogesterone acetate (MPA) reduces secretion of IL-6 and PTHrP from human breast cancer cells. MPA dose-dependently decreases the secretion and mRNA expression of IL-6 and PTHrP in the KTC-2 cells. [2]

Medroxyprogesterone acetate (MPA) and dexamethasone dose dependently increases alpha-ENaC promoter-driven luciferase activity in M-1 cells, which is not inhibited by Org31710, indicating that Medroxyprogesterone acetate regulates alpha-ENaC in a PR-independent manner. Medroxyprogesterone acetate and dexamethasone, but not progesterone, dose dependently increases alpha-ENaC and sgk1 mRNA in M-1 and in Madin-Darby canine kidney-C7 cells, both collecting duct cell lines. [3]

Medroxyprogesterone acetate (MPA) (0.1 nM) significantly enhances the in vitro production of specific immunoglobulin G (IgG) antibodies, an effect that appears to involve the interaction of the progestin with PRG receptors[4]
Cell Research Cell lines ISK cells
Concentrations 29.3 µM
Incubation Time 48 h
Method

Cells were treated with various concentrations of drug for 48 h.
In Vivo
In vivo

Medroxyprogesterone acetate (MPA) impairs delayed memory retention on the water radial-arm maze (WRAM), and exacerbates overnight forgetting on the Morris maze (MM) in aged ovariectomized (OVX) rats. Medroxyprogesterone acetate (MPA) significantly and progesterone marginally decreases GAD levels in the hippocampus, and both MPA and progesterone significantly increases GAD levels in the entorhinal cortex. [5]
Animal Research Animal Models Wistar albino female rats
Dosages 1, 2, 4, or 8 mg/kg
Administration i.p.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05178563 Not yet recruiting
Inflammation|Periodontal Diseases
University College London
 September 1 2024 Not Applicable
NCT06297096 Not yet recruiting
Systemic Sclerosis|Interstitial Lung Disease
National Institute of Geriatrics Rheumatology and Rehabilitation Poland|Medical Research Agency Poland
 April 1 2024 Phase 3
NCT06193135 Not yet recruiting
Infertility Female|Reproductive Sterility
Instituto Valenciano de Infertilidad IVI VALENCIA
 March 1 2024 Not Applicable

Chemical Information & Solubility

Molecular Weight 386.52 Formula

C24H34O4
CAS No. 71-58-9 SDF Download MPA (Medroxyprogesterone acetate) SDF
Smiles CC1CC2C(CCC3(C2CCC3(C(=O)C)OC(=O)C)C)C4(C1=CC(=O)CC4)C
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 12 mg/mL ( (31.04 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 12 mg/mL

Water : Insoluble


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In vivo
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