Home Endocrinology & Hormones Estrogen/progestogen Receptor agonist Levonorgestrel For research use only.

Levonorgestrel

Synonyms: D-Norgestrel

Levonorgestrel (D-Norgestrel) is a female hormone that prevents ovulation.

Levonorgestrel Chemical Structure

Levonorgestrel Chemical Structure

CAS No. 797-63-7

Purity & Quality Control

Levonorgestrel Related Products

Signaling Pathway

Estrogen/progestogen Receptor Signaling Pathways

Estrogen/progestogen Receptor Signaling Pathway

Biological Activity

Description Levonorgestrel (D-Norgestrel) is a female hormone that prevents ovulation.
Targets
Progesterone receptor [1]
In vitro
In vitro Levonorgestrel suppresses the stimulation of progesterone secretion induced by oLH, dibutyryl-cAMP and Pregnenolone in rats luteal cells. [1] Levonorgestrel also inhibits constrictions evoked by either a high potassium (K(+)) solution or phorbol myristate acetate (PMA) in the absence and presence of extracellular calcium (Ca(2+)). Levonorgestrel depresses contractions evoked by Ca(2+) and reduces (45)Ca(2+) influx in depolarized veins. Levonorgestrel increases levels of cyclic AMP and inhibits PMA-induced activation of protein kinase C in veins. Levonorgestrel causes endothelium-independent relaxations of jugular veins via inhibition of Ca(2+) entry and of protein kinase Cactivation. [2] Levonorgestrel inhibition of both estrogen-induced pituitary weight increment and hyperprolactinemia is reduced by mifepristone, whereas Flutamide is unable to block Levonorgestrel effects [3]
In Vivo
In vivo Levonorgestrel down-regulates the mRNA expression of follicle-stimulating hormone receptor (FSHR), luteinizing hormone receptor (LHR), estrogen receptor (ER) β and progesterone receptor (PR) in the ovary, and ERα and PR in the uterus of Mongolian gerbils. [4] Levonorgestrel causes a significant upregulation of the mRNA expression of the gene encoding luteinising hormone β-subunit (lhβ) and the suppression of the mRNA expression of the gene encoding follicle-stimulating hormone β-subunit (fshβ) in the pituitary of both male and female roach. Levonorgestrel disrupts the reproductive system of pubertalroach by affecting the pituitary gonadotropin expression and the sex steroid levels in pubertal roach (Rutilus rutilus). [5]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06380205 Recruiting
Healthy Participants
Incyte Corporation
 May 7 2024 Phase 1
NCT06188026 Recruiting
Healthy Volunteers (Non-alcoholic Steatohepatitis)
Novo Nordisk A/S
 December 18 2023 Phase 1
NCT05896384 Recruiting
Healthy
Boehringer Ingelheim
 December 7 2023 Phase 1
NCT05700812 Recruiting
IUD|IUD Insertion Complication|IUD; Complications
University of California Davis
 February 1 2023 Not Applicable
NCT05671653 Terminated
Obesity
Pfizer
 January 19 2023 Phase 1

Chemical Information & Solubility

Molecular Weight 312.45 Formula

C21H28O2
CAS No. 797-63-7 SDF Download Levonorgestrel SDF
Smiles CCC12CCC3C(C1CCC2(C#C)O)CCC4=CC(=O)CCC34
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 62 mg/mL ( (198.43 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 5 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Levonorgestrel | Levonorgestrel ic50 | Levonorgestrel price | Levonorgestrel cost | Levonorgestrel solubility dmso | Levonorgestrel purchase | Levonorgestrel manufacturer | Levonorgestrel research buy | Levonorgestrel order | Levonorgestrel mouse | Levonorgestrel chemical structure | Levonorgestrel mw | Levonorgestrel molecular weight | Levonorgestrel datasheet | Levonorgestrel supplier | Levonorgestrel in vitro | Levonorgestrel cell line | Levonorgestrel concentration | Levonorgestrel nmr