Home Metabolism PPAR agonist - P450 (e.g. CYP17) inhibitor - Autophagy activator Fenofibrate For research use only.

Fenofibrate

Synonyms: NSC-281319

Fenofibrate is a compound of the fibrate class and fibric acid derivative. Fenofibrate is a selective agonist of PPARα with EC50 of 30 μM. Fenofibrate binds to and inhibits cytochrome P450 epoxygenase (CYP)2C with IC50 of 0.2 μM, 0.7 μM and 9.7 μM for CYP2C19, CYP2B6 and CYP2C9, respectively. Fenofibrate induces autophagy.

Fenofibrate Chemical Structure

Fenofibrate Chemical Structure

CAS No. 49562-28-9

Purity & Quality Control

Fenofibrate Related Products

Signaling Pathway

PPAR Signaling Pathways

PPAR Signaling Pathway

Biological Activity

Description Fenofibrate is a compound of the fibrate class and fibric acid derivative. Fenofibrate is a selective agonist of PPARα with EC50 of 30 μM. Fenofibrate binds to and inhibits cytochrome P450 epoxygenase (CYP)2C with IC50 of 0.2 μM, 0.7 μM and 9.7 μM for CYP2C19, CYP2B6 and CYP2C9, respectively. Fenofibrate induces autophagy.
Targets
PPARα [1] CYP2C19 [3]
(Cell-free assay)		 CYP2B6 [3]
(Cell-free assay)		 CYP2C9 [3]
(Cell-free assay)
0.2 μM 0.7 μM 9.7 μM
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05514119 Recruiting
Liver Transplant
Mayo Clinic
 August 17 2022 Phase 2
NCT04650152 Completed
Hypertriglyceridemia|Metabolic Syndrome
Abbott
 October 27 2020 --
NCT03869931 Unknown status
Diabetes Mellitus|Diabetic Nephropathies
Singapore General Hospital|National Medical Research Council (NMRC) Singapore
 March 8 2019 Phase 3
NCT03557983 Unknown status
Radiodermatitis
Second Affiliated Hospital of Soochow University
 June 13 2018 Not Applicable

Chemical Information & Solubility

Molecular Weight 360.83 Formula

C20H21ClO4
CAS No. 49562-28-9 SDF Download Fenofibrate SDF
Smiles CC(C)OC(=O)C(C)(C)OC1=CC=C(C=C1)C(=O)C2=CC=C(C=C2)Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 72 mg/mL ( (199.53 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 72 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Fenofibrate | Fenofibrate ic50 | Fenofibrate price | Fenofibrate cost | Fenofibrate solubility dmso | Fenofibrate purchase | Fenofibrate manufacturer | Fenofibrate research buy | Fenofibrate order | Fenofibrate mouse | Fenofibrate chemical structure | Fenofibrate mw | Fenofibrate molecular weight | Fenofibrate datasheet | Fenofibrate supplier | Fenofibrate in vitro | Fenofibrate cell line | Fenofibrate concentration | Fenofibrate nmr