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Technical Data
| Formula | C20H21ClO4 |
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| Molecular Weight | 360.83 | CAS No. | 49562-28-9 | |
| Solubility (25°C)* | In vitro | DMSO | 72 mg/mL (199.53 mM) | |
| Ethanol | 72 mg/mL (199.53 mM) | |||
| Water | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Preparing Stock Solutions
Biological Activity
| Description | Fenofibrate is a compound of the fibrate class and fibric acid derivative. Fenofibrate is a selective agonist of PPARα with EC50 of 30 μM. Fenofibrate binds to and inhibits cytochrome P450 epoxygenase (CYP)2C with IC50 of 0.2 μM, 0.7 μM and 9.7 μM for CYP2C19, CYP2B6 and CYP2C9, respectively. Fenofibrate induces autophagy. | ||||||||
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Protocol (from reference)
References
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Customer Product Validation
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Data from [Data independently produced by , , Diabetes, 2017, 66(9):2387-2399]
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Data from [Data independently produced by , , Food Funct, 2018, 9(12):6608-6617]
Selleck's Fenofibrate has been cited by 16 publications
| Propafenone facilitates mitochondrial-associated ferroptosis and synergizes with immunotherapy in melanoma [ J Immunother Cancer, 2024, 12(11)e009805] | PubMed: 39581704 |
| Exserolide J ameliorates lipid accumulation in vitro by regulating liver X receptor alpha and peroxisome proliferator-activated receptor alpha proteins [ Heliyon, 2024, 10(11):e31861] | PubMed: 38947487 |
| EDARADD promotes colon cancer progression by suppressing E3 ligase Trim21-mediated ubiquitination and degradation of Snail [ Cancer Lett, 2023, 10.1016/j.canlet.2023.216427] | PubMed: 37838280 |
| Erythrocyte transglutaminase-2 combats hypoxia and chronic kidney disease by promoting oxygen delivery and carnitine homeostasis [ Cell Metab, 2022, 34(2):299-316.e6] | PubMed: 35108516 |
| Repositioning Fenofibrate to Reactivate p53 and Reprogram the Tumor-Immune Microenvironment in HPV+ Head and Neck Squamous Cell Carcinoma [ Cancers (Basel), 2022, 14(2)282] | PubMed: 35053444 |
| Pharmaceutical targeting of succinate dehydrogenase in fibroblasts controls bleomycin-induced lung fibrosis [ Redox Biol, 2021, 46:102082] | PubMed: 34343908 |
| The Cordyceps militaris-Derived Polysaccharide CM1 Alleviates Atherosclerosis in LDLR(-/-) Mice by Improving Hyperlipidemia [ Front Mol Biosci, 2021, 8:783807] | PubMed: 34966782 |
| The Meningioma Enhancer Landscape Delineates Novel Subgroups and Drives Druggable Dependencies [ Cancer Discov, 2020, CD-20-0160] | PubMed: 32703768 |
| The marine-derived furanone reduces intracellular lipid accumulation in vitro by targeting LXRα and PPARα [ J Cell Mol Med, 2020, 24(6):3384-3398] | PubMed: 31981312 |
| The marine-derived furanone reduces intracellular lipid accumulation in vitro by targeting LXRα and PPARα. [ J Cell Mol Med, 2020, 24(6):3384-3398] | PubMed: 31981312 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.