Home Metabolism PPAR activator Alpinetin For research use only.

Alpinetin

Alpinetin, a composition of Alpinia katsumadai Hayata, has been reported to have a number of biological properties, such as antibacterial, antitumor and other important therapeutic activities. Alpinetin is a flavonoid isolated from Alpinia katsumadai Hayata, activates activates PPAR-γ, with potent anti-inflammatory activity.

Alpinetin Chemical Structure

Alpinetin Chemical Structure

CAS No. 36052-37-6

Purity & Quality Control

Alpinetin Related Products

Signaling Pathway

PPAR Signaling Pathways

PPAR Signaling Pathway

Biological Activity

Description Alpinetin, a composition of Alpinia katsumadai Hayata, has been reported to have a number of biological properties, such as antibacterial, antitumor and other important therapeutic activities. Alpinetin is a flavonoid isolated from Alpinia katsumadai Hayata, activates activates PPAR-γ, with potent anti-inflammatory activity.
In vitro
In vitro Alpinetin markedly inhibits the LPS- induced TNF-α, IL-6 and IL-1β production both in vitro and vivo. Furthermore, alpinetin blocks the phosphorylation of IκBα protein, p65, p38 and extracellular signal-regulated kinase (ERK) in LPS stimulated RAW 264.7 cells[1]. Alpinetin can suppress the proliferation and invasiveness of GSCs and induce apoptosis in GSCs[2].
Cell Research Cell lines Raw 264.7 cells
Concentrations 0–300 μg/ml
Incubation Time 1 h
Method Cell viability is evaluated by MTT assay. Briefly, 100 μl cells are plated at a density of 4×105 cells/ml in 96-well plates in a 37 ℃, 5% CO2 incubator for 1 h. Then the cells are treated with 50 μl of alpinetin of different concentrations (0-300 μg/ml) for 1 h, followed by stimulation with 50 μl LPS (4 μg/ml). The total volume of each well is 200 μl, and the concentrations of Alpinetin and LPS are four times diluted finally. After 18 h of LPS stimulation, 20 μl MTT (5 mg/ml) is added to each well, and the cells are further incubated for an additional 4 h. The supernatant is removed and the formation of formazan is resolved with 150 μl/well of DMSO. The optical density is measured at 570 nm on a microplate reader.
In Vivo
In vivo Alpinetin attenuates lung histopathologic changes in mouse models[1].
Animal Research Animal Models Male BALB/c mice
Dosages 50 mg/kg
Administration i.p.

Chemical Information & Solubility

Molecular Weight 270.28 Formula

C16H14O4
CAS No. 36052-37-6 SDF Download Alpinetin SDF
Smiles COC1=CC(=CC2=C1C(=O)CC(O2)C3=CC=CC=C3)O
Storage (From the date of receipt)

In vitro
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DMSO : 54 mg/mL ( (199.79 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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