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Carbohydrate Metabolism Inhibitors/Modulators

Other Metabolism Related Inhibitors

Dehydrogenase Transferase DPP Aminopeptidase Procollagen C Proteinase P450 (e.g. CYP17) Phospholipase (e.g. PLA) Factor Xa PDE DHFR

Isoform-selective Products

Cat.No. Product Name Information Product Use Citations Product Validations
S1950 Metformin Hydrochloride Metformin Hydrochloride (1,1-Dimethylbiguanide Hydrochloride) is a highly effective Antihyperglycemic Agent, which primarily decreases hyperglycemia in hepatocytes by suppressing hepatic gluconeogenesis (glucose production by the liver). It also promotes mitophagy in mononuclear cells and induces apoptosis of lung cancer cells through activating the JNK/p38 MAPK pathway and GADD153.
Cell Biosci, 2025, 15(1):156
mBio, 2025, e0063425
Placenta, 2025, 165:50-61
Verified customer review of Metformin Hydrochloride
S4701 2-DG (2-Deoxy-D-glucose) 2-DG (2-Deoxy-D-glucose), an analog of glucose, is a glycolytic inhibitor with antiviral activity. 2-Deoxy-D-glucose induces apoptosis and inhibits Herpes Simplex Virus type-1 (HSV-1) receptor expression.
Signal Transduct Target Ther, 2025, 10(1):341
Nat Commun, 2025, 16(1):212
Cancer Commun (Lond), 2025, 10.1002/cac2.70036
Verified customer review of 2-DG (2-Deoxy-D-glucose)
S5426 Bromopyruvic acid (3-BP) Bromopyruvic acid (3-BP) is a hexokinase II inhibitor with Ki of 2.4 mM for glycolysis/hexokinase inhibition. It is inhibitor of tumour cell energy metabolism and chemopotentiator of platinum drugs.
Signal Transduct Target Ther, 2025, 10(1):341
Alzheimers Res Ther, 2025, 17(1):72
iScience, 2024, 27(3):109246
S6921 Dorzagliatin Dorzagliatin (HMS-5552, RO-5305552, Sinogliatin) is a dual-acting glucokinase (GK) activator that improves glycaemic control and pancreatic β-cell function in patients with type 2 diabetes.
Pharmaceuticals (Basel), 2025, 18(6)927
bioRxiv, 2025, 2025.04.03.647023
bioRxiv, 2025, 2023.08.11.552890
S2155 LY2608204 LY2608204 activates glucokinase (GK) with EC50 of 42 nM. Phase 2.
Sci Rep, 2017, 7:44681
Nat Commun, 2016, 7:11463
Verified customer review of LY2608204
S1271 Acarbose Acarbose(BAY g 5421,Prandase, Precose, Glucobay, Bay-g 5421) is an inhibitor of intestinal alpha-glucosidase, used to treat type 2 diabetes mellitus.
Infect Genet Evol, 2020, 81:104210
E1353 AZD1656 AZD1656 is a potent, selective and orally active activator of glucokinase. This compound has the potential for type 2 diabetes research.
Liver Res-Prc, 2023, Volume 7, Issue 2 Pages 124-135
S3839 1-Deoxynojirimycin 1-Deoxynojirimycin (duvoglustat, moranolin) is a potent α-glucosidase inhibitor and most commonly found in mulberry leaves. It has therapeutic potency against diabetes mellitus.
J Biol Chem, 2022, 298(12):102643
S3918 4',7-Dimethoxy-5-Hydroxyflavone 4',7-Dimethoxy-5-Hydroxyflavone (4',7-dimethylapigenin, apigenin dimethylether, apigenin 7,4'-dimethyl ether) inhibits α-glucosidase and α-amylase enzymes and enhances 2-NBDG uptake in L6 cells.
Nat Cell Biol, 2022, 24(3):364-372
S4101 Voglibose Voglibose (AO 128) is an N-substituted derivative of valiolamine, excellent inhibitory activity against α-glucosidases and its action against hyperglycemia and various disorders caused by hyperglycemia.
G3 (Bethesda), 2020, 4;10(5):1585-1597