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Catalog No. Product Name Information Product Use Citations Product Validations
S1950 Metformin HCl Metformin HCl (1,1-Dimethylbiguanide HCl) decreases hyperglycemia in hepatocytes primarily by suppressing glucose production by the liver (hepatic gluconeogenesis). Metformin promotes mitophagy in mononuclear cells. Metformin induces apoptosis of lung cancer cells through activating JNK/p38 MAPK pathway and GADD153.
Nat Commun, 2024, 15(1):1785
J Clin Invest, 2024, e175023
EBioMedicine, 2024, 102:105090
S4701 2-DG (2-Deoxy-D-glucose) 2-DG (2-Deoxy-D-glucose), an analog of glucose, is a glycolytic inhibitor with antiviral activity. 2-Deoxy-D-glucose induces apoptosis and inhibits Herpes Simplex Virus type-1 (HSV-1) receptor expression.
EMBO Mol Med, 2024, 10.1038/s44321-024-00136-9
Int J Biol Sci, 2024, 20(3):848-863
Int J Biol Macromol, 2024, 280(Pt 4):135580
S2610 Lonidamine Lonidamine is an orally administered small molecule hexokinase inactivator.
Cancer Lett, 2024, 589:216824
Mol Oncol, 2023, 17(9):1821-1843
Mol Oncol, 2023, 17(9):1821-1843
S5426 Bromopyruvic acid (3-BP) Bromopyruvic acid (3-BP) is a hexokinase II inhibitor with Ki of 2.4 mM for glycolysis/hexokinase inhibition. It is inhibitor of tumour cell energy metabolism and chemopotentiator of platinum drugs.
iScience, 2024, 27(3):109246
Cancer Sci, 2024, 10.1111/cas.16204
EMBO Rep, 2023, e56325.
S2035 Epalrestat Epalrestat is an aldose reductase inhibitor with IC50 of 72 nM.
Cell Rep Med, 2023, 4(6):101056
Cell Rep Med, 2023, 4(6):101056
Free Radic Biol Med, 2021, 163:220-233
S2155 LY2608204 LY2608204 activates glucokinase (GK) with EC50 of 42 nM. Phase 2.
Sci Rep, 2017, 7:44681
Nat Commun, 2016, 7:11463
S1271 Acarbose Acarbose(BAY g 5421,Prandase, Precose, Glucobay, Bay-g 5421) is an inhibitor of intestinal alpha-glucosidase, used to treat type 2 diabetes mellitus.
Infect Genet Evol, 2020, 81:104210
S3300 Desoxyrhaponticin Desoxyrhaponticin (DC, DES), a stilbene glycoside from Rheum tanguticum Maxim. ex Balf. (rhubarb) which is a traditional Chinese nutritional food, is a fatty acid synthase (FAS/FASN) inhibitor. Desoxyrhaponticin (DC, DES) is also a competitive inhibitor of glucose uptake with IC50 of 148.3 μM and 30.9 μM in rabbit intestinal membrane vesicles and in rat everted gut sleeves, respectively. Desoxyrhaponticin has apoptotic effect on human cancer cells.
Nat Metab, 2021, 10.1038/s42255-021-00479-4
S3839 1-Deoxynojirimycin 1-Deoxynojirimycin (duvoglustat, moranolin) is a potent α-glucosidase inhibitor and most commonly found in mulberry leaves. It has therapeutic potency against diabetes mellitus.
J Biol Chem, 2022, 298(12):102643
S6921 Dorzagliatin Dorzagliatin (HMS-5552, RO-5305552, Sinogliatin) is a dual-acting glucokinase (GK) activator that improves glycaemic control and pancreatic β-cell function in patients with type 2 diabetes.
Proc Natl Acad Sci U S A, 2022, 119(31):e2204407119
S3918 4',7-Dimethoxy-5-Hydroxyflavone 4',7-Dimethoxy-5-Hydroxyflavone (4',7-dimethylapigenin, apigenin dimethylether, apigenin 7,4'-dimethyl ether) inhibits α-glucosidase and α-amylase enzymes and enhances 2-NBDG uptake in L6 cells.
Nat Cell Biol, 2022, 24(3):364-372
S4101 Voglibose Voglibose (AO 128) is an N-substituted derivative of valiolamine, excellent inhibitory activity against α-glucosidases and its action against hyperglycemia and various disorders caused by hyperglycemia.
G3 (Bethesda), 2020, 4;10(5):1585-1597
S3278 Kaempferol-3-O-neohesperidoside Kaempferol 3-neohesperidoside (Kaempferol 3-O-neohesperidoside), a flavonoid isolated from the leaf extract of Primula latifolia Lapeyr. and Primula vulgaris Hudson, stimulates glycogen synthesis in rat soleus muscle via PI3K - GSK-3 pathway and MAPK - PP1 pathway.
S3245 Nodakenetin Nodakenetin (NANI), a plant-derived coumarin isolated from Angelica decursiva, inhibits α-glucosidase, PTP1B, rat lens aldose reductase (RLAR), AChE, BChE, and β-site amyloid precursor protein cleaving enzyme 1 (BACE1). Nodakenetin alters the protein expression of Bax and Bcl-2, and prompts mitochondrial apoptosis. Nodakenetin exhibits anti-tumor activity.
E1353 AZD1656 AZD1656 is a potent, selective and orally active activator of glucokinase. AZD1656 has the potential for type 2 diabetes research.
S2589 Miglitol Miglitol is an oral anti-diabetic drug.
E0477 N-Caffeoyl O-methyltyramine N-Caffeoyl O-methyltyramine is a class of alkaloid isolated from Cuscuta reflexa with strong inhibitory activity against α-glucosidase with IC50 of 103.58 μM.
E3072 Paniculata Extract Paniculata Extract is extracted from Microcos paniculata L., which shows various biological functions including antioxidant activity and α-glucosidase inhibitory effect.
S3243 Zeaxanthin Zeaxanthin, the carotenoid alcohol participates in the xanthophyll cycle, activates the extrinsic apoptosis pathway which induces apoptosis on uveal melanoma cells with IC50 value 40.8 µM.
E2846 FBPase-1 inhibitor-1 FBPase-1 inhibitor-1, an allosteric inhibitor of fructose-1,6-bisphosphatase (FBPase-1), exhibits similar potency (IC50 = 3.4 μM using MG; = 4.0 μM in the coupled format) in these two distinct assays of FBPase-1 activity.
S0553 Butyl isobutyl phthalate  Butyl isobutyl phthalate (BIP), isolated from the rhizoid of Laminaria japonica, is a non-competitive inhibitor of α-glucosidase with IC50 of 38 μM. Butyl isobutyl phthalate displays a significant hypoglycemic effect and has the potential for diabetes treatment.
E3107 Andrographis Herba Extract Andrographis Herba Extract is obtained from the aerial part of Andrographis paniculata (Burm. F.) Nees, has various activities including antimicrobial and antioxidant, antimalarial, antiangiogenic, anti-inflammatory, anti-diabetic, and in vitro α-glucosidase and α-amylase enzyme inhibitory activities.
S3527 AM2394 AM-2394 is a structurally distinct glucokinase activator (GKA), activates glucokinase (GK) with an EC50 of 60 nM.
E3333 Viburnum Dilatatum Extract Viburnum Dilatatum Extract is extrcated from Viburnum Dilatatum, which has alpha-glucosidase inhibitory activities and an antihyperglycemic action.
S0808 Ketohexokinase inhibitor 1 Ketohexokinase inhibitor 1 (PF-06835919, MDK1846) is a potent inhibitor of ketohexokinase (KHK) with IC50 of 8.4 nM and 66 nM for KHK-C and KHK-A, respectively.
E2509 WAY-297848 WAY-297848 is a novel glucokinase activator with potential use as a drug for the prevention or treatment of hyperglycemia, diabetes, obesity, dyslipidemia, metabolic syndrome, etc.
S9378 4',5-Dihydroxyflavone 4',5-Dihydroxyflavone inhibits soybean LOX-1 and yeast α-glucosidase.
S3796 Rebaudioside A Rebaudioside A (Stevia Extract, Reb A, Glycoside A3, Stevioside A3), an natural sweetening ingredient extracted from the stevia leaf, is used in powder or liquid form to heighten sweetening intensity and improve taste. Rebaudioside A is a steviol glycoside, α-glucosidase inhibitor with IC50 of 35.01 μg/ml.can inhibit ATP-sensitive K+-channels.
S2949 KPLH1130 KPLH1130 is a specific inhibitor of pyruvate dehydrogenase kinase (PDK) that blocks macrophage polarization and attenuates proinflammatory responses.
S4793 Cedryl acetate Cedryl Acetate (Cedrol acetate, Cedranyl acetate), an acetylated from cedarwood oil, has been applied to chemistry for its properties as a chiral and cell signaling reagent with antifungal and immunotoxicity functions. Cedryl acetate exhibits α-glucosidase inhibitory activity.
E4014 4-Nitrophenyl alpha-D-glucopyranoside 4-Nitrophenyl alpha-D-glucopyranoside is a chromogenic substrate in the α-glucosidase inhibition assay.
S5426 Bromopyruvic acid (3-BP) Bromopyruvic acid (3-BP) is a hexokinase II inhibitor with Ki of 2.4 mM for glycolysis/hexokinase inhibition. It is inhibitor of tumour cell energy metabolism and chemopotentiator of platinum drugs.
iScience, 2024, 27(3):109246
Cancer Sci, 2024, 10.1111/cas.16204
EMBO Rep, 2023, e56325.
S3300 Desoxyrhaponticin Desoxyrhaponticin (DC, DES), a stilbene glycoside from Rheum tanguticum Maxim. ex Balf. (rhubarb) which is a traditional Chinese nutritional food, is a fatty acid synthase (FAS/FASN) inhibitor. Desoxyrhaponticin (DC, DES) is also a competitive inhibitor of glucose uptake with IC50 of 148.3 μM and 30.9 μM in rabbit intestinal membrane vesicles and in rat everted gut sleeves, respectively. Desoxyrhaponticin has apoptotic effect on human cancer cells.
Nat Metab, 2021, 10.1038/s42255-021-00479-4
S3918 4',7-Dimethoxy-5-Hydroxyflavone 4',7-Dimethoxy-5-Hydroxyflavone (4',7-dimethylapigenin, apigenin dimethylether, apigenin 7,4'-dimethyl ether) inhibits α-glucosidase and α-amylase enzymes and enhances 2-NBDG uptake in L6 cells.
Nat Cell Biol, 2022, 24(3):364-372
S4101 Voglibose Voglibose (AO 128) is an N-substituted derivative of valiolamine, excellent inhibitory activity against α-glucosidases and its action against hyperglycemia and various disorders caused by hyperglycemia.
G3 (Bethesda), 2020, 4;10(5):1585-1597
S3245 Nodakenetin Nodakenetin (NANI), a plant-derived coumarin isolated from Angelica decursiva, inhibits α-glucosidase, PTP1B, rat lens aldose reductase (RLAR), AChE, BChE, and β-site amyloid precursor protein cleaving enzyme 1 (BACE1). Nodakenetin alters the protein expression of Bax and Bcl-2, and prompts mitochondrial apoptosis. Nodakenetin exhibits anti-tumor activity.
S2589 Miglitol Miglitol is an oral anti-diabetic drug.
E0477 N-Caffeoyl O-methyltyramine N-Caffeoyl O-methyltyramine is a class of alkaloid isolated from Cuscuta reflexa with strong inhibitory activity against α-glucosidase with IC50 of 103.58 μM.
E3072 Paniculata Extract Paniculata Extract is extracted from Microcos paniculata L., which shows various biological functions including antioxidant activity and α-glucosidase inhibitory effect.
S3243 Zeaxanthin Zeaxanthin, the carotenoid alcohol participates in the xanthophyll cycle, activates the extrinsic apoptosis pathway which induces apoptosis on uveal melanoma cells with IC50 value 40.8 µM.
E2846 FBPase-1 inhibitor-1 FBPase-1 inhibitor-1, an allosteric inhibitor of fructose-1,6-bisphosphatase (FBPase-1), exhibits similar potency (IC50 = 3.4 μM using MG; = 4.0 μM in the coupled format) in these two distinct assays of FBPase-1 activity.
S0553 Butyl isobutyl phthalate  Butyl isobutyl phthalate (BIP), isolated from the rhizoid of Laminaria japonica, is a non-competitive inhibitor of α-glucosidase with IC50 of 38 μM. Butyl isobutyl phthalate displays a significant hypoglycemic effect and has the potential for diabetes treatment.
E3107 Andrographis Herba Extract Andrographis Herba Extract is obtained from the aerial part of Andrographis paniculata (Burm. F.) Nees, has various activities including antimicrobial and antioxidant, antimalarial, antiangiogenic, anti-inflammatory, anti-diabetic, and in vitro α-glucosidase and α-amylase enzyme inhibitory activities.
E3333 Viburnum Dilatatum Extract Viburnum Dilatatum Extract is extrcated from Viburnum Dilatatum, which has alpha-glucosidase inhibitory activities and an antihyperglycemic action.
S0808 Ketohexokinase inhibitor 1 Ketohexokinase inhibitor 1 (PF-06835919, MDK1846) is a potent inhibitor of ketohexokinase (KHK) with IC50 of 8.4 nM and 66 nM for KHK-C and KHK-A, respectively.
S9378 4',5-Dihydroxyflavone 4',5-Dihydroxyflavone inhibits soybean LOX-1 and yeast α-glucosidase.
S3796 Rebaudioside A Rebaudioside A (Stevia Extract, Reb A, Glycoside A3, Stevioside A3), an natural sweetening ingredient extracted from the stevia leaf, is used in powder or liquid form to heighten sweetening intensity and improve taste. Rebaudioside A is a steviol glycoside, α-glucosidase inhibitor with IC50 of 35.01 μg/ml.can inhibit ATP-sensitive K+-channels.
S2949 KPLH1130 KPLH1130 is a specific inhibitor of pyruvate dehydrogenase kinase (PDK) that blocks macrophage polarization and attenuates proinflammatory responses.
S4793 Cedryl acetate Cedryl Acetate (Cedrol acetate, Cedranyl acetate), an acetylated from cedarwood oil, has been applied to chemistry for its properties as a chiral and cell signaling reagent with antifungal and immunotoxicity functions. Cedryl acetate exhibits α-glucosidase inhibitory activity.
S6921 Dorzagliatin Dorzagliatin (HMS-5552, RO-5305552, Sinogliatin) is a dual-acting glucokinase (GK) activator that improves glycaemic control and pancreatic β-cell function in patients with type 2 diabetes.
Proc Natl Acad Sci U S A, 2022, 119(31):e2204407119
E1353 AZD1656 AZD1656 is a potent, selective and orally active activator of glucokinase. AZD1656 has the potential for type 2 diabetes research.
S3527 AM2394 AM-2394 is a structurally distinct glucokinase activator (GKA), activates glucokinase (GK) with an EC50 of 60 nM.
E2509 WAY-297848 WAY-297848 is a novel glucokinase activator with potential use as a drug for the prevention or treatment of hyperglycemia, diabetes, obesity, dyslipidemia, metabolic syndrome, etc.
S4701 2-DG (2-Deoxy-D-glucose) 2-DG (2-Deoxy-D-glucose), an analog of glucose, is a glycolytic inhibitor with antiviral activity. 2-Deoxy-D-glucose induces apoptosis and inhibits Herpes Simplex Virus type-1 (HSV-1) receptor expression.
EMBO Mol Med, 2024, 10.1038/s44321-024-00136-9
Int J Biol Sci, 2024, 20(3):848-863
Int J Biol Macromol, 2024, 280(Pt 4):135580
S2610 Lonidamine Lonidamine is an orally administered small molecule hexokinase inactivator.
Cancer Lett, 2024, 589:216824
Mol Oncol, 2023, 17(9):1821-1843
Mol Oncol, 2023, 17(9):1821-1843
S2035 Epalrestat Epalrestat is an aldose reductase inhibitor with IC50 of 72 nM.
Cell Rep Med, 2023, 4(6):101056
Cell Rep Med, 2023, 4(6):101056
Free Radic Biol Med, 2021, 163:220-233
S2155 LY2608204 LY2608204 activates glucokinase (GK) with EC50 of 42 nM. Phase 2.
Sci Rep, 2017, 7:44681
Nat Commun, 2016, 7:11463
S3839 1-Deoxynojirimycin 1-Deoxynojirimycin (duvoglustat, moranolin) is a potent α-glucosidase inhibitor and most commonly found in mulberry leaves. It has therapeutic potency against diabetes mellitus.
J Biol Chem, 2022, 298(12):102643
S3278 Kaempferol-3-O-neohesperidoside Kaempferol 3-neohesperidoside (Kaempferol 3-O-neohesperidoside), a flavonoid isolated from the leaf extract of Primula latifolia Lapeyr. and Primula vulgaris Hudson, stimulates glycogen synthesis in rat soleus muscle via PI3K - GSK-3 pathway and MAPK - PP1 pathway.

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