Home Metabolism PPAR agonist Eupatilin For research use only.

Eupatilin

Synonyms: NSC 122413

Eupatilin (NSC 122413), a major flavonoid from Artemisia plants, possesses various beneficial biological effects including anti-inflammation, anti-tumor, anti-cancer, anti-allergy, and anti-oxidation activity. Eupatilin, a lipophilic flavonoid isolated from Artemisia species, is a PPARα agonist, and possesses anti-apoptotic, anti-oxidative and anti-inflammatory activities.

Eupatilin Chemical Structure

Eupatilin Chemical Structure

CAS No. 22368-21-4

Purity & Quality Control

Eupatilin Related Products

Signaling Pathway

PPAR Signaling Pathways

PPAR Signaling Pathway

Biological Activity

Description Eupatilin (NSC 122413), a major flavonoid from Artemisia plants, possesses various beneficial biological effects including anti-inflammation, anti-tumor, anti-cancer, anti-allergy, and anti-oxidation activity. Eupatilin, a lipophilic flavonoid isolated from Artemisia species, is a PPARα agonist, and possesses anti-apoptotic, anti-oxidative and anti-inflammatory activities.
In vitro
In vitro Eupatilin has been reported to induce apoptosis in human gastric cancer AGS cells, also triggers differentiation of these cells. Treatment of AGS cells with eupatilin induces cell cycle arrest at the G1 phase with the concomitant induction of p21cip1, a cell cycle inhibitor. It also markedly induces trefoil factor1(TFF1). Eupatilin dramatically induces redistribution of tight junction proteins such as occludin and ZO-1, and F-actin at the junctional region between cells. It also induces phosphorylation of extracellular signal-regulated kinase 2 and p38 kinase. Eupatilin is known to inhibit the growth of MCF-10A-ras cells by inhibiting the expression of cell cycle regulators such as cyclinD1, cyclinB1, Cdk2, and Cdc2[1].
Cell Research Cell lines Human gastric epithelial AGS cells
Concentrations 10-500 μM
Incubation Time 24, 48, 72 h
Method Cellular viability is determined by PI incorporation. Cells are treated with various reagents, washed with PBS twice, resuspended in PBS containing 20 μg/ml PI, and then immediately analyzed on a FACSCalibur. PI-positive cells are counted as dead cells and the remaining cells are designated as viable cells.
In Vivo
In vivo Treatment with eupatilin significantly decreases serum alanine aminotransferase and serum aspartate aminotransferase as well as liver histologic changes. Eupatilin also preventes hepatic glutathione depletion and increases malondialdehyde levels induced by Ischemia-reperfusion injury (IRI). It improves the acute hepatic IRI by reducing inflammation and apoptosis[2]. Oral administration of eupatilin (10 mg/kg) in a therapeutic paradigm significantly reduces brain infarction and improves neurological functions in tMCAO-challenged mice. Eupatilin administration reduces the number of Iba1-immunopositive cells across ischemic brain and induces their morphological changes from amoeboid into ramified in the ischemic core, which is accompanied with reduced microglial proliferation in ischemic brain. Eupatilin suppresses NF-κB signaling activities in ischemic brain by reducing IKKα/β phosphorylation, IκBα phosphorylation, and IκBα degradation[3].
Animal Research Animal Models C57BL/6 mice
Dosages 10 mg/kg
Administration oral

Chemical Information & Solubility

Molecular Weight 344.32 Formula

C18H16O7
CAS No. 22368-21-4 SDF Download Eupatilin SDF
Smiles COC1=C(C=C(C=C1)C2=CC(=O)C3=C(O2)C=C(C(=C3O)OC)O)OC
Storage (From the date of receipt)

In vitro
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