Home Endocrinology & Hormones Estrogen/progestogen Receptor chemical Estrone For research use only.

Estrone

Estrone is an estrogenic hormone.

Estrone Chemical Structure

Estrone Chemical Structure

CAS No. 53-16-7

Purity & Quality Control

Estrone Related Products

Signaling Pathway

Estrogen/progestogen Receptor Signaling Pathways

Estrogen/progestogen Receptor Signaling Pathway

Biological Activity

Description Estrone is an estrogenic hormone.
Targets
estrogen receptor [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05900895 Not yet recruiting
Metastatic Breast Cancer
Mary D Chamberlin|Dartmouth-Hitchcock Medical Center
 May 2024 Phase 1
NCT06136208 Recruiting
Climacteric Syndrome|Menopause|Hypoestrogenism
Science Valley Research Institute|Biòs Farmacêutica
 December 13 2023 Not Applicable
NCT05974449 Recruiting
Breast Cancer Female
The First Affiliated Hospital with Nanjing Medical University
 August 24 2023 Phase 2
NCT05967819 Recruiting
Amenorrhea Secondary
University of Colorado Colorado Springs
 August 9 2023 Not Applicable
NCT05607004 Recruiting
Breast Neoplasms|Invasive Breast Cancer|Estrogen-receptor-positive Breast Cancer|HER2-negative Breast Cancer
Atossa Therapeutics Inc.|InClin
 February 14 2023 Phase 2

Chemical Information & Solubility

Molecular Weight 270.37 Formula

C18H22O2
CAS No. 53-16-7 SDF Download Estrone SDF
Smiles CC12CCC3C(C1CCC2=O)CCC4=C3C=CC(=C4)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 54 mg/mL ( (199.72 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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