Home Endocrinology & Hormones Estrogen/progestogen Receptor chemical Drospirenone For research use only.

Drospirenone

Synonyms: ZK 3059

Drospirenone (ZK 3059) is a synthetic progestin that is an analog to spironolactone.

Drospirenone Chemical Structure

Drospirenone Chemical Structure

CAS No. 67392-87-4

Purity & Quality Control

Drospirenone Related Products

Signaling Pathway

Estrogen/progestogen Receptor Signaling Pathways

Estrogen/progestogen Receptor Signaling Pathway

Biological Activity

Description Drospirenone (ZK 3059) is a synthetic progestin that is an analog to spironolactone.
Targets
progestogen Receptor [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06345560 Not yet recruiting
Contraception
Chulalongkorn University
 April 2024 Phase 1|Phase 2
NCT05934942 Terminated
Healthy
Boehringer Ingelheim
 September 8 2023 Phase 1
NCT06039826 Active not recruiting
Overweight
Eli Lilly and Company
 September 12 2023 Phase 1
NCT04792385 Completed
Safety
Estetra
 December 28 2020 Phase 3

Chemical Information & Solubility

Molecular Weight 366.49 Formula

C24H30O3
CAS No. 67392-87-4 SDF Download Drospirenone SDF
Smiles CC12CCC(=O)C=C1C3CC3C4C2CCC5(C4C6CC6C57CCC(=O)O7)C
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 73 mg/mL ( (199.18 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 12 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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