Home Metabolism P450 (e.g. CYP17) inhibitor 7-Hydroxyflavone For research use only.

7-Hydroxyflavone

7-Hydroxyflavone is a potent inhibitor of CYP1A1 with a Ki value of 0.015 μM and exhibits 6-fold greater selectivity for CYP1A1 over CYP1A2. It also has excellent antioxidant properties and great potential to be applied as medicines.

7-Hydroxyflavone Chemical Structure

7-Hydroxyflavone Chemical Structure

CAS No. 6665-86-7

Purity & Quality Control

Batch: S538001 DMSO]47 mg/mL]false]]]false]]]false Purity: 99.86%
99.86

7-Hydroxyflavone Related Products

Signaling Pathway

P450 (e.g. CYP17) Signaling Pathways

P450 (e.g. CYP17) Signaling Pathway

Biological Activity

Description 7-Hydroxyflavone is a potent inhibitor of CYP1A1 with a Ki value of 0.015 μM and exhibits 6-fold greater selectivity for CYP1A1 over CYP1A2. It also has excellent antioxidant properties and great potential to be applied as medicines.
Targets
CYP1A1 [1]
(Cell-free assay)
0.015 μM(Ki)

Chemical Information & Solubility

Molecular Weight 238.24 Formula

C15H10O3
CAS No. 6665-86-7 SDF --
Smiles C1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C=C(C=C3)O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 47 mg/mL ( (197.28 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


Molecular Weight Calculator

In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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