Home Endocrinology & Hormones Adrenergic Receptor inhibitor 3-Nitro-L-tyrosine For research use only.

3-Nitro-L-tyrosine

Synonyms: 3-NT, N-Tyr, MNT

3-Nitro-L-tyrosine (3-NT, N-Tyr, MNT), synthesized from L-tyrosine by peroxynitrite, is a product of nitric oxide and superoxide. 3-Nitro-L-tyrosine inhibits the hemodynamic responses to angiotensin II, possibly through the inhibition of alpha 1-adrenoceptor-mediated events.

3-Nitro-L-tyrosine Chemical Structure

3-Nitro-L-tyrosine Chemical Structure

CAS No. 621-44-3

Purity & Quality Control

Batch: S634501 DMSO]2 mg/mL]false]Water]1 mg/mL]false]Ethanol]Insoluble]false Purity: 99.50%
99.50

3-Nitro-L-tyrosine Related Products

Signaling Pathway

Adrenergic Receptor Signaling Pathways

Adrenergic Receptor Signaling Pathway

Biological Activity

Description 3-Nitro-L-tyrosine (3-NT, N-Tyr, MNT), synthesized from L-tyrosine by peroxynitrite, is a product of nitric oxide and superoxide. 3-Nitro-L-tyrosine inhibits the hemodynamic responses to angiotensin II, possibly through the inhibition of alpha 1-adrenoceptor-mediated events.
Targets
alpha 1-adrenoceptor [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06126315 Not yet recruiting
Amyotrophic Lateral Sclerosis
Mario Negri Institute for Pharmacological Research|University of Sydney|FightMND
 June 2024 Phase 2|Phase 3
NCT05258669 Recruiting
COVID-19
Ocugen
 February 20 2022 Phase 2|Phase 3
NCT04259255 Active not recruiting
Amyotrophic Lateral Sclerosis|ALS
Mitsubishi Tanabe Pharma America Inc.|Massachusetts General Hospital
 October 21 2019 --
NCT03456882 Completed
Amyotrophic Lateral Sclerosis
Mario Negri Institute for Pharmacological Research|ALS Association|Get out ONLUS
 May 30 2017 Phase 2

Chemical Information & Solubility

Molecular Weight 226.19 Formula

C9H10N2O5
CAS No. 621-44-3 SDF --
Smiles NC(CC1=CC(=C(O)C=C1)[N+]([O-])=O)C(O)=O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 2 mg/mL ( (8.84 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 1 mg/mL

Ethanol : Insoluble


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In vivo
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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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