17-Hydroxyprogesterone

17-Hydroxyprogesterone (17-OHP) is an endogenous progestogen as well as chemical intermediate in the biosynthesis of other steroid hormones, including the corticosteroids and the androgens and the estrogens.

17-Hydroxyprogesterone Chemical Structure

17-Hydroxyprogesterone Chemical Structure

CAS No. 68-96-2

Purity & Quality Control

Batch: S450701 DMSO]66 mg/mL]false]Ethanol]66 mg/mL]false]Water]Insoluble]false Purity: 99.94%
99.94

17-Hydroxyprogesterone Related Products

Biological Activity

Description 17-Hydroxyprogesterone (17-OHP) is an endogenous progestogen as well as chemical intermediate in the biosynthesis of other steroid hormones, including the corticosteroids and the androgens and the estrogens.
In vitro
In vitro 17α-OHP is an agonist of the progesterone receptor (PR) similarly to progesterone, albeit weakly in comparison[1]. It is a chemical intermediate in the biosynthesis of steroid hormones, including the androgen and estrogen sex hormones and the glucocorticoids and mineralocorticoids.
In Vivo
In vivo 17-Hydroxyprogesterone is a potent steroid inducer of GVBD (germinal vesicle breakdown)[3].
Animal Research Animal Models Male Panulirus polyphagus
Dosages 0.01, 0.1 μg/g
Administration Injection laterally to fifth abdominal segment
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06402344 Recruiting
Hormones; Abuse|Cardiovascular Diseases
Hospital Israelita Albert Einstein
May 27 2024 --
NCT05907291 Recruiting
Congenital Adrenal Hyperplasia|Classic Congenital Adrenal Hyperplasia
Crinetics Pharmaceuticals Inc.
July 3 2023 Phase 2
NCT05669950 Recruiting
Congenital Adrenal Hyperplasia
H. Lundbeck A/S
December 19 2022 Phase 1
NCT05299554 Enrolling by invitation
Congenital Adrenal Hyperplasia
Diurnal Limited
April 1 2022 Phase 3

Chemical Information & Solubility

Molecular Weight 330.46 Formula

C21H30O3

CAS No. 68-96-2 SDF Download 17-Hydroxyprogesterone SDF
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 66 mg/mL ( (199.72 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 66 mg/mL

Water : Insoluble


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In vivo
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