Home Microbiology Bacterial chemical - DHFR inhibitor - Antibiotics chemical Trimethoprim For research use only.

Trimethoprim

Synonyms: BW 56-72, NIH 204, NSC-106568

Trimethoprim (BW 56-72, NIH 204, NSC-106568) is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections.

Trimethoprim Chemical Structure

Trimethoprim Chemical Structure

CAS No. 738-70-5

Purity & Quality Control

Trimethoprim Related Products

Biological Activity

Description Trimethoprim (BW 56-72, NIH 204, NSC-106568) is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections.
In vitro
In vitro Trimethoprim acts by interfering with the action of bacterial dihydrofolate reductase, inhibiting synthesis of tetrahydrofolic acid. The Inhibition starves the bacteria of nucleotides necessary for DNA replication causing, in certain circumstances, cell lethality due to thymineless death.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05817253 Completed
Clinical Audit|Quality Improvement
University of British Columbia|Ministry of Health British Columbia
 September 23 2021 Not Applicable
NCT03424525 Active not recruiting
Bacterial Infections
University of Pennsylvania
 February 1 2018 Phase 1
NCT02475876 Completed
Bacterial Infections
Michael Cohen-Wolkowiez|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|Duke University
 November 2015 Phase 1

Chemical Information & Solubility

Molecular Weight 290.32 Formula

C14H18N4O3
CAS No. 738-70-5 SDF Download Trimethoprim SDF
Smiles COC1=CC(=CC(=C1OC)OC)CC2=CN=C(N=C2N)N
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 58 mg/mL ( (199.77 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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