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Talatisamine

Talatisamine, a delphinine type alkaloid extracted from Aconitum talassicum, is a newly identified K+ channel blocker with hypotensive and antiarrhythmic activities.

Talatisamine Chemical Structure

Talatisamine Chemical Structure

CAS No. 20501-56-8

Purity & Quality Control

Talatisamine Related Products

Biological Activity

Description Talatisamine, a delphinine type alkaloid extracted from Aconitum talassicum, is a newly identified K+ channel blocker with hypotensive and antiarrhythmic activities.
Targets
IK channel [1]
146 μM
In vitro
In vitro Talatisamine is a specific blocker for IK channel. External application of talatisamine reversibly inhibited the delayed rectifier K+ current (IK) with an IC50 value of 146.0±5.8 μM in a voltage-dependent manner, but exhibited very slight blocking effect on the voltage-gated Na+ and Ca2+ currents even at the high concentration of 1-3 mM in rat hippocampal neurons. Talatisamine had no allosteric action on IK channel and was a pure blocker binding to the external pore entry of the channel[1].

Chemical Information & Solubility

Molecular Weight 421.57 Formula

C24H39NO5
CAS No. 20501-56-8 SDF --
Smiles CCN1CC2(CCC(C34C2CC(C31)C5(CC(C6CC4C5C6O)OC)O)OC)COC
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 35 mg/mL ( (83.02 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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