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Sulfamethoxypyridazine

Name: Sulfamethoxypyridazine
Brand: Selleck Chemicals
SKU: S4250
Rating: 5 (1 reviews)

Synonyms: CL 13494

Catalog No.S4250 Purity:99.82%

Sulfamethoxypyridazine (CL 13494) is a long-acting sulfonamide for treatment of Dermatitis herpetiformis.

Sulfamethoxypyridazine Chemical Structure

CAS No. 80-35-3

Purity & Quality Control

Batch: S425001 DMSO]56 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.82%

99.82

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Biological Activity

Description	Sulfamethoxypyridazine (CL 13494) is a long-acting sulfonamide for treatment of Dermatitis herpetiformis.

In Vivo
In vivo	Sulfamethoxypyridazine is found to be highly effective in a preliminary study of P. carinii-infected rats. Sulfamethoxypyridazine is also found to be as effective as sulfamethoxazole in P. carinii-infected rats at 1 mg/kg of body weight/day. Sulfamethoxypyridazine is effective aganist a murine model of P. carinii with ED50s of 0.06 mg/kg/day and 0.08 mg/kg/day as determined by the Giemsa and silver stain scores, respectively. Sulfamethoxypyridazine at either 0.1 mg/kg/day or 0.3 mg/kg/day is found to be significantly more effective than sulfamethoxazole at 0.47 mg/kg/day) aganist a murine model of P. carinii. ^[1] Sulfamethoxypyridazine exhibits the biological half lives of 11.0 hours and 13.7 hours following im and sc administration, respectively, in goats. Sulfamethoxypyridazine exhibits the systemic availabilities of 68.6% and 58.7% following im and sc administration, respectively, in goats. ^[2] Sulfamethoxypyridazine exhibits the distribution and elimination half life of 0.1 hour and 6.28 hours, respectively, in goats. Sulfamethoxypyridazine exhibits the values of apparent volume of distribution at steady state and total body clearance of 0.39 mL/kg/min and 0.73 mL/kg/min, respectively, in goats. ^[3]

References

Chemical Information & Solubility

Molecular Weight	280.3	Formula	C₁₁H₁₂N₄O₃S
CAS No.	80-35-3	SDF	Download Sulfamethoxypyridazine SDF
Smiles	COC1=NN=C(C=C1)NS(=O)(=O)C2=CC=C(C=C2)N
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 56 mg/mL ( (199.78 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
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Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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