Home Others ADC Cytotoxin chemical - Antibody-Drug Conjugate chemical Sacituzumab-govitecan For research use only.

Sacituzumab-govitecan

Synonyms: IMMU-132

Sacituzumab govitecan (IMMU-132) is an antibody-drug conjugate (ADC) targeting Trop-2 for delivery of SN-38, showing anticancer activity. Sacituzumab govitecan has a molecular weight of 160KDa. This product is supplied as 10mg/ml PBS solution.This product is discontinued. We recommend the replacement products: D4002.

Sacituzumab-govitecan Chemical Structure

Sacituzumab-govitecan Chemical Structure

CAS No. 1491917-83-9 (ADC)

Click to purchase products related to Sacituzumab govitecan

Purity & Quality Control

Sacituzumab-govitecan Related Products

Biological Activity

Description Sacituzumab govitecan (IMMU-132) is an antibody-drug conjugate (ADC) targeting Trop-2 for delivery of SN-38, showing anticancer activity. Sacituzumab govitecan has a molecular weight of 160KDa. This product is supplied as 10mg/ml PBS solution.This product is discontinued. We recommend the replacement products: D4002.
In vitro
In vitro

Sacituzumab govitecan (IMMU-132), an antibody-drug conjugate (ADC) made from a humanized anti-Trop-2 monoclonal antibody (hRS7) conjugated with the active metabolite of irinotecan, SN-38, shows anticancer activity in cancers expressing Trop-2, including gastric and pancreatic cancer.
Cell Research Cell lines BxPC-3 cells
Concentrations 20 µg/ml
Incubation Time 30 minutes
Method

Cells were treated with indicated concentration of drug for 30 minutes.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06161532 Not yet recruiting
Small Cell Carcinoma of the Bladder|Small Cell Carcinoma of the Urinary Tract|Squamous Cell Carcinoma of the Bladder|Squamous Cell Carcinoma of the Urinary Tract|Primary Adenocarcinoma of the Bladder|Primary Adenocarcinoma of the Urinary Tract|Renal Medullary Carcinoma|Squamous Cell Carcinoma of the Penis
National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC)
 May 15 2024 Phase 2
NCT06236269 Not yet recruiting
Breast Cancer Stage IV
SOLTI Breast Cancer Research Group
 February 20 2024 Phase 2
NCT06028932 Recruiting
Ovarian Carcinoma
Yale University|Gilead Sciences
 January 8 2024 Phase 2
NCT06167317 Recruiting
Advanced Solid Tumors
Gilead Sciences
 January 9 2024 Phase 1
NCT05838521 Recruiting
Cervical Cancer
Yale University|Gilead Sciences
 June 2 2023 Phase 2

Chemical Information & Solubility

Molecular Weight 160000 Formulation 10mg/mL in PBS
DAR 7.6 Antibody Sacituzumab
ADC Cytotoxin SN-38 Formula C76H104N12O24S
CAS No. 1491917-83-9 (ADC) Storage (From the date of receipt) 1 year -80°C in solvent
Shipping Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

In vitro
Batch:


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.

Frequently Asked Questions

Question 1:
What’s the solvent of this ADC drug? And what‘s its concentration?

Answer:
The solvent is a PBS solution. The concentration is 10mg/ml.

Question 2:
What is the molecular weight of Sacituzumab govitecan (IMMU-132)?

Answer:
Sacituzumab govitecan (IMMU-132) contains on average 7 to 8 molecules of SN-38 per antibody molecule. Sacituzumab govitecan (IMMU-132) has a molecular weight of approximately 160 kilodaltons. The molecular weight of the drug (SN-38) and linker other than the antibody is 1601.8.

Tags: buy Sacituzumab-govitecan | Sacituzumab-govitecan ic50 | Sacituzumab-govitecan price | Sacituzumab-govitecan cost | Sacituzumab-govitecan solubility dmso | Sacituzumab-govitecan purchase | Sacituzumab-govitecan manufacturer | Sacituzumab-govitecan research buy | Sacituzumab-govitecan order | Sacituzumab-govitecan mouse | Sacituzumab-govitecan chemical structure | Sacituzumab-govitecan mw | Sacituzumab-govitecan molecular weight | Sacituzumab-govitecan datasheet | Sacituzumab-govitecan supplier | Sacituzumab-govitecan in vitro | Sacituzumab-govitecan cell line | Sacituzumab-govitecan concentration | Sacituzumab-govitecan nmr