Home Metabolism Carbohydrate Metabolism inhibitor Rebaudioside A For research use only.

Rebaudioside A

Synonyms: Reb A, Glycoside A3, Stevioside A3

Rebaudioside A (Stevia Extract, Reb A, Glycoside A3, Stevioside A3), an natural sweetening ingredient extracted from the stevia leaf, is used in powder or liquid form to heighten sweetening intensity and improve taste. Rebaudioside A is a steviol glycoside, α-glucosidase inhibitor with IC50 of 35.01 μg/ml.can inhibit ATP-sensitive K+-channels.

Rebaudioside A Chemical Structure

Rebaudioside A Chemical Structure

CAS No. 58543-16-1

Purity & Quality Control

Batch: S379601 DMSO]40 mg/mL]false]]]false]]]false Purity: 98%
98

Rebaudioside A Related Products

Biological Activity

Description Rebaudioside A (Stevia Extract, Reb A, Glycoside A3, Stevioside A3), an natural sweetening ingredient extracted from the stevia leaf, is used in powder or liquid form to heighten sweetening intensity and improve taste. Rebaudioside A is a steviol glycoside, α-glucosidase inhibitor with IC50 of 35.01 μg/ml.can inhibit ATP-sensitive K+-channels.
In vitro
In vitro

Rebaudioside A potentiates glucose-stimulated insulin secretion on MIN6 cells. It does not shange intracellular cAMP level of isolated mouse islets. Rebaudioside A modulates the effect of glucose on insulin secretion via indirect inhibition of the KATP channels, thereby allowing β cells to depolarize and generate action potentials, events that are important for glucose-stimulated insulin secretion[1].
Cell Research Cell lines MIN6 cells
Concentrations 10-13 to 10-7 μM
Incubation Time 60 min
Method

After 30 min of preincubation with Krebs-Ringer bicarbonate buffer without glucose, cells are exposed to the indicated conditions for 60 min; the solution is then collected and subjected to radioimmunoassay for the detection of insulin levels.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03510624 Completed
Type 2 Diabetes Mellitus
Universitaire Ziekenhuizen KU Leuven
 November 9 2018 Phase 1

Chemical Information & Solubility

Molecular Weight 967.01 Formula

C44H70O23
CAS No. 58543-16-1 SDF Download Rebaudioside A SDF
Smiles CC12CCCC(C1CCC34C2CCC(C3)(C(=C)C4)OC5C(C(C(C(O5)CO)O)OC6C(C(C(C(O6)CO)O)O)O)OC7C(C(C(C(O7)CO)O)O)O)(C)C(=O)OC8C(C(C(C(O8)CO)O)O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 40 mg/mL ( (41.36 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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