Home Neuronal Signaling Dopamine Receptor antagonist Raclopride For research use only.

Raclopride

Raclopride is a selective dopamine D2/D3 receptor antagonist that discriminates between dopamine-mediated motor functions. Raclopride binds to D2 and D3 receptors with dissociation constants of between 1.8 nM and 3.5 nM, but has a very low affinity for D4 receptors.

Raclopride Chemical Structure

Raclopride Chemical Structure

CAS No. 84225-95-6

Purity & Quality Control

Batch: E012501 DMSO]69 mg/mL]false]Ethanol]69 mg/mL]false]Water]1 mg/mL]false Purity: 99.98%
99.98

Raclopride Related Products

Signaling Pathway

Dopamine Receptor Signaling Pathways

Dopamine Receptor Signaling Pathway

Biological Activity

Description Raclopride is a selective dopamine D2/D3 receptor antagonist that discriminates between dopamine-mediated motor functions. Raclopride binds to D2 and D3 receptors with dissociation constants of between 1.8 nM and 3.5 nM, but has a very low affinity for D4 receptors.
Targets
Dopamine D2 receptor [1] Dopamine D3 receptor [1]
1.8 nM(Ki) 3.5 nM(Ki)
In Vivo
In vivo

Raclopride is an antagonist of central dopaminergic D2 receptors, possessing antiaggressive effect of raclopride with very little motor impairment and some increase in exploratory behavior.[2]
Animal Research Animal Models Albino male mice of the OF1 strain
Dosages 0.1, 0.3, or 0.6 mg/kg
Administration i.p.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05359887 Recruiting
Obesity
University Medical Center Groningen
 December 1 2022 Not Applicable
NCT03648892 Completed
Obesity|Healthy Volunteers|Overweight
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|National Institutes of Health Clinical Center (CC)
 September 21 2018 Early Phase 1
NCT02744391 Completed
Major Depressive Disorder|Dysthymia|Depression Not Otherwise Specified|Decreased Processing Speed|Decreased Gait Speed
New York State Psychiatric Institute
 August 24 2016 Phase 4
NCT03026036 Completed
Major Depressive Disorder
Mclean Hospital
 April 2016 --

Chemical Information & Solubility

Molecular Weight 347.24 Formula

C15H20Cl2N2O3
CAS No. 84225-95-6 SDF --
Smiles CCN1CCCC1CNC(=O)C2=C(OC)C(=CC(=C2O)Cl)Cl
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 69 mg/mL ( (198.7 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 69 mg/mL

Water : 1 mg/mL


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Raclopride | Raclopride supplier | purchase Raclopride | Raclopride cost | Raclopride manufacturer | order Raclopride | Raclopride distributor