Home Neuronal Signaling Dopamine Receptor inhibitor Trifluoperazine 2HCl For research use only.

Trifluoperazine 2HCl

Synonyms: SKF5019

Trifluoperazine (NSC-17474, RP-7623, SKF-5019) 2HCl is a dopamine D2 receptor inhibitor with IC50 of 1.1 nM. Trifluoperazine also inhibits calmodulin (CaM).

Trifluoperazine 2HCl Chemical Structure

Trifluoperazine 2HCl Chemical Structure

CAS No. 440-17-5

Purity & Quality Control

Trifluoperazine 2HCl Related Products

Signaling Pathway

Dopamine Receptor Signaling Pathways

Dopamine Receptor Signaling Pathway

Biological Activity

Description Trifluoperazine (NSC-17474, RP-7623, SKF-5019) 2HCl is a dopamine D2 receptor inhibitor with IC50 of 1.1 nM. Trifluoperazine also inhibits calmodulin (CaM).
Targets
Dopamine D2 receptor [1]
1.1 nM
In vitro
In vitro Trifluoperazine binds to α1A- and α1B-adrenoceptor with Ki value of 27.6 nM and 19.2 nM, respectively, with α1B/α1A ratio of 0.7. [2] Trifluoperazine inhibits Mycobacterium tuberculosis (Mtb) with MICs of 7.6 μg/mL. [3] Trifluoperazine (< 14.78 mM) suppresses the activities of the mouse splenic NK cell cytotoxicity and the effector-target cell conjugation in a dose dependent manner. Trifluoperazine suppresses interferon-alpha or interleukin-2 induced augmentation of the cytolytic activity of NK cells. [4] Trifluoperazine inhibits the gene expression of voltage-dependent potassium channel Kv2.1 from human brain (hKv2.1). [5]
In Vivo
In vivo Trifluoperazine dose dependently decreases avoidance responses and increases response failures in rats where behavior is maintained under a discrete-trial avoidance. [6]

Chemical Information & Solubility

Molecular Weight 480.42 Formula

C21H24F3N3S.2HCl
CAS No. 440-17-5 SDF Download Trifluoperazine 2HCl SDF
Smiles CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F.Cl.Cl
Storage (From the date of receipt)

In vitro
Batch:

Water : 96 mg/mL

Ethanol : 96 mg/mL

DMSO : 88 mg/mL ( (183.17 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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