Home Neuronal Signaling Dopamine Receptor inhibitor Domperidone For research use only.

Domperidone

Domperidone is an oral dopamine D2 receptor antagonist, used to treat nausea and vomiting.

Domperidone Chemical Structure

Domperidone Chemical Structure

CAS No. 57808-66-9

Purity & Quality Control

Domperidone Related Products

Signaling Pathway

Dopamine Receptor Signaling Pathways

Dopamine Receptor Signaling Pathway

Biological Activity

Description Domperidone is an oral dopamine D2 receptor antagonist, used to treat nausea and vomiting.
Targets
Dopamine D2 receptor [1]
In vitro
In vitro Domperidone (a D2R antagonist) inhibits Equilibrative NT1 (ENT1) activity more in the presence than in the absence of Bromocriptine and displays an IC50 value lower than that of Bromocriptine or Ergovaline in Madin-Darby bovine kidney (MDBK) cells. [1]
In Vivo
In vivo Domperidone (0.1 mg/kg) results in a significant decrease in feeding behavior and stimulation of basal metabolism, but has no effect on locomotor activity of rats in a Phenomaster system. [2] Domperidone (1.1 mg/kg and 5.5 mg/kg, oral) significantly increases laminar microvascular blood flow (LMBF) in horses, compared with baseline values, beginning 4 hours after administration, and this effect persisted for at least 8 hours. Domperidone (0.2 mg/kg, i.v.) significantly increases laminar microvascular blood flow (LMBF) in horses, compared with baseline values, at 10 and 12 hours after administration. [3] Domperidone can ameliorate deleterious reproductive effects and reduce weight gain associated with fescue toxicosis in heifers. [4] Domperidone-treated mares have shorter gestation duration and foaled closer to their expected parturition date than did control mares. Domperidone-treated mares have higher Mammary gland scores and serum prolactin concentration. [5] Domperidone (5 mg/kg, oral) increases peak plasma acetaminophen concentration and area under the curve in rats, indicating increased gastric emptying. Domperidone decreases the dopamine-induced contractile activity of midjejunal longitudinal muscle strips in rats. [6]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05570292 Completed
Gastric Residual Volume
Ain Shams University
 October 10 2022 Phase 3
NCT04653584 Terminated
Parkinson Disease
Assistance Publique - Hôpitaux de Paris
 January 1 2021 --
NCT03837067 Completed
Parkinson''s Disease
Assistance Publique - Hôpitaux de Paris
 July 17 2018 --
NCT01710462 Withdrawn
Gastroesophageal Reflux Disease
Eurofarma Laboratorios S.A.
 August 2013 Phase 3
NCT01907633 Completed
Death Sudden Cardiac
Janssen Research & Development LLC
 December 2011 --

Chemical Information & Solubility

Molecular Weight 425.91 Formula

C22H24ClN5O2
CAS No. 57808-66-9 SDF Download Domperidone SDF
Smiles C1CN(CCC1N2C3=C(C=C(C=C3)Cl)NC2=O)CCCN4C5=CC=CC=C5NC4=O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 48 mg/mL ( (112.69 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 1 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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