Home Neuronal Signaling Dopamine Receptor agonist PD128907 HCl For research use only.

PD128907 HCl

PD 128907 HCl is a potent and selective dopamine D3 receptor agonist, with EC50 of 0.64 nM, exhibits 53-fold selectivity over dopamine D2 receptor.

PD128907 HCl Chemical Structure

PD128907 HCl Chemical Structure

CAS No. 112960-16-4

Purity & Quality Control

Batch: S216801 DMSO]12 mg/mL]false]Water]3 mg/mL]false]Ethanol]Insoluble]false Purity: 99.44%
99.44

PD128907 HCl Related Products

Signaling Pathway

Dopamine Receptor Signaling Pathways

Dopamine Receptor Signaling Pathway

Biological Activity

Description PD 128907 HCl is a potent and selective dopamine D3 receptor agonist, with EC50 of 0.64 nM, exhibits 53-fold selectivity over dopamine D2 receptor.
Targets
D3 receptor [1]
0.64 nM(EC50)
In vitro
In vitro PD 128907 HCl is a potent and selective dopamine D3 receptor agonist, with EC50 of 0.64 nM, exhibits 53-fold selectivity over dopamine D2 receptor. [1] When using [3H]spiperone as the radioligand in CHOKl-cells, PD 128907 exhibits about a l000-fold selectivity for human D3 receptors (Ki, 1 nM) versus human D2 receptors (Ki, 1183 nM) and a l0000-fold selectivity versus human D4receptors (Ki, 7000 nM) [2] PD 128907 is used for studying the role of these receptors in the brain, in roles such as inhibitory autoreceptors that act to limit further dopamine release.[3]
In Vivo
In vivo PD 128907 is active in reducing DA synthesis both in normal and γ-butyrolactone (GBL) treated rats. [4] PD 128907 (3 mg/kg) reduces toxicity from cocaine overdose, completely prevented the convulsant and lethal effects of cocaine. [5] The protection occurs through a D3-linked mechanism and that protection is extended to seizure kindling. [6]
Animal Research Animal Models Mouse
Dosages 3 mg/kg
Administration i.p.

Chemical Information & Solubility

Molecular Weight 285.77 Formula

C14H19NO3.HCl
CAS No. 112960-16-4 SDF Download PD128907 HCl SDF
Smiles CCCN1CCOC2C1COC3=C2C=C(C=C3)O.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 12 mg/mL ( (41.99 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 3 mg/mL

Ethanol : Insoluble


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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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