Trifluoperazine 2HCl

Catalog No.S3201 Batch:S320102

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Technical Data

Formula

C21H24F3N3S.2HCl
Molecular Weight 480.42 CAS No. 440-17-5
Solubility (25°C)* In vitro DMSO 96 mg/mL (199.82 mM)
Water 96 mg/mL (199.82 mM)
Ethanol 96 mg/mL (199.82 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description Trifluoperazine (NSC-17474, RP-7623, SKF-5019) 2HCl is a dopamine D2 receptor inhibitor with IC50 of 1.1 nM. Trifluoperazine also inhibits calmodulin (CaM).
Targets
Dopamine D2 receptor [1]
1.1 nM
In vitro Trifluoperazine binds to α1A- and α1B-adrenoceptor with Ki value of 27.6 nM and 19.2 nM, respectively, with α1B/α1A ratio of 0.7. [2] Trifluoperazine inhibits Mycobacterium tuberculosis (Mtb) with MICs of 7.6 μg/mL. [3] Trifluoperazine (< 14.78 mM) suppresses the activities of the mouse splenic NK cell cytotoxicity and the effector-target cell conjugation in a dose dependent manner. Trifluoperazine suppresses interferon-alpha or interleukin-2 induced augmentation of the cytolytic activity of NK cells. [4] Trifluoperazine inhibits the gene expression of voltage-dependent potassium channel Kv2.1 from human brain (hKv2.1). [5]
In vivo Trifluoperazine dose dependently decreases avoidance responses and increases response failures in rats where behavior is maintained under a discrete-trial avoidance. [6]

Protocol (from reference)

Selleck's Trifluoperazine 2HCl has been cited by 8 publications

High-throughput drug screen identifies calcium and calmodulin inhibitors that reduce JCPyV infection [ Antiviral Res, 2024, 222:105817] PubMed: 38246207
The Food and Drug Administration-approved antipsychotic drug trifluoperazine, a calmodulin antagonist, inhibits viral replication through PERK-eIF2α axis [ Front Microbiol, 2022, 13:979904] PubMed: 36386620
In vitro effects of opicapone on activity of human UDP-glucuronosyltransferases isoforms [ Toxicol Lett, 2022, 367:3-8] PubMed: 35810997
Comparison of the drug-drug interactions potential of ibrutinib and acalabrutinib via inhibition of UDP-glucuronosyltransferase [ Toxicol Appl Pharmacol, 2021, 424:115595] PubMed: 34038714
In vitro inhibition of human UDP-glucuronosyltransferase (UGT) 1A1 by osimertinib, and prediction of in vivo drug-drug interactions [ Toxicol Lett, 2021, 348:10-17] PubMed: 34044055
A Low Dose of Aripiprazole Has the Strongest Sensitization Effect Among 19 Repositioned Bipolar Drugs in P-gp-overexpressing Drug-resistant Cancer Cells [ Anticancer Res, 2021, 41(2):687-697] PubMed: 33517273
Inhibition of human UDP-glucuronosyltransferase enzyme by Dabrafenib: Implications for drug-drug interactions [ Biomed Chromatogr, 2021, e5205] PubMed: 34192355
Inhibition of Human UDP-Glucuronosyltransferase Enzyme by Belinostat: Implications for Drug-Drug Interactions [ Toxicol Lett, 2020, S0378-4274(20)30494-X] PubMed: 33290829

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

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