Home Immunology & Inflammation Nrf2 inhibitor - Apoptosis related inhibitor - Immunology & Inflammation related inhibitor Oxysophocarpine For research use only.

Oxysophocarpine

Synonyms: OSC

Oxysophocarpine (OSC) is an alkaloid extracted from Sophora alopecuroides. Oxysophocarpine inhibits the growth and metastasis of oral squamous cell carcinoma (OSCC) by targeting the Nrf2/HO-1 axis. OSC protects cells against apoptosis and inflammatory responses and compromised miR-155 activity by attenuating MAPK and NF-κB pathways.

Oxysophocarpine Chemical Structure

Oxysophocarpine Chemical Structure

CAS No. 26904-64-3

Purity & Quality Control

Batch: E012901 DMSO]52 mg/mL]false]Water]52 mg/mL]false]Ethanol]52 mg/mL]false Purity: 99.99%
99.99

Oxysophocarpine Related Products

Biological Activity

Description Oxysophocarpine (OSC) is an alkaloid extracted from Sophora alopecuroides. Oxysophocarpine inhibits the growth and metastasis of oral squamous cell carcinoma (OSCC) by targeting the Nrf2/HO-1 axis. OSC protects cells against apoptosis and inflammatory responses and compromised miR-155 activity by attenuating MAPK and NF-κB pathways.
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Opioid Use Disorder
Yale University|National Institute on Drug Abuse (NIDA)
 July 2024 Phase 1
NCT05447286 Recruiting
Opioid Use Disorder
Yale University|National Institute on Drug Abuse (NIDA)|Aptinyx
 May 15 2023 Phase 1
NCT03620578 Active not recruiting
Non Hodgkin Lymphoma|Lymphoma B-Cell|High-grade B-cell Lymphoma|MYC Translocation|BCL-2 Translocation
Stichting Hemato-Oncologie voor Volwassenen Nederland
 August 1 2018 Phase 2
NCT02753764 Completed
Corticosteroid Resistant (CR) Asthmatics
National Jewish Health
 January 2017 Phase 2
NCT01277874 Withdrawn
Respiratory Distress Syndrome|Prematurity
University of Utah
 December 2014 Not Applicable

Chemical Information & Solubility

Molecular Weight 262.35 Formula

C15H22N2O2
CAS No. 26904-64-3 SDF --
Smiles [O-][N+]12CCCC3CN4C(CC=CC4=O)C(CCC1)C23
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 52 mg/mL ( (198.2 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 52 mg/mL

Ethanol : 52 mg/mL


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