Home Immunology & Inflammation Nrf2 activator Bardoxolone (CDDO) For research use only.

Bardoxolone (CDDO)

Synonyms: RTA 401

Bardoxolone (CDDO), acts by releasing Nrf2 from KEAP1,is a highly potent activator of Nrf2 that induce programmed cell death (apoptosis) in cancer cells.

Bardoxolone (CDDO) Chemical Structure

Bardoxolone (CDDO) Chemical Structure

CAS No. 218600-44-3

Purity & Quality Control

Batch: S664701 DMSO]6 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 98.45%
98.45

Bardoxolone (CDDO) Related Products

Biological Activity

Description Bardoxolone (CDDO), acts by releasing Nrf2 from KEAP1,is a highly potent activator of Nrf2 that induce programmed cell death (apoptosis) in cancer cells.
Targets
Nrf2 [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02036970 Completed
Pulmonary Arterial Hypertension|Pulmonary Hypertension|Interstitial Lung Disease|Idiopathic Interstitial Pneumonia|Idiopathic Pulmonary Fibrosis|Sarcoidosis|Respiratory Bronchiolitis Associated Interstitial Lung Disease|Desquamative Interstitial Pneumonia|Cryptogenic Organizing Pneumonia|Acute Interstitial Pneumonitis|Idiopathic Lymphoid Interstitial Pneumonia|Idiopathic Pleuroparenchymal Fibroelastosis
Reata a wholly owned subsidiary of Biogen|Biogen
 May 31 2014 Phase 2
NCT01598363 Completed
Healthy Volunteers
Reata a wholly owned subsidiary of Biogen|Biogen
 June 30 2012 Phase 1
NCT01551446 Withdrawn
Renal Insufficiency Chronic|Diabetes Mellitus Type 2
Reata a wholly owned subsidiary of Biogen|Biogen
 April 30 2012 Phase 1
NCT01503866 Completed
Healthy
Reata a wholly owned subsidiary of Biogen|Biogen
 December 1 2011 Phase 1
NCT01461161 Completed
Healthy Volunteers
Reata a wholly owned subsidiary of Biogen|Biogen
 October 31 2011 Phase 1

Chemical Information & Solubility

Molecular Weight 491.66 Formula

C31H41NO4
CAS No. 218600-44-3 SDF --
Smiles CC1(CCC2(CCC3(C(C2C1)C(=O)C=C4C3(CCC5C4(C=C(C(=O)C5(C)C)C#N)C)C)C)C(=O)O)C
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 6 mg/mL ( (12.2 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
Batch:

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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