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Technical Data
| Formula | C31H41NO4 |
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| Molecular Weight | 491.66 | CAS No. | 218600-44-3 | |
| Solubility (25°C)* | In vitro | DMSO | 6 mg/mL (12.2 mM) | |
| Water | Insoluble | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Bardoxolone (CDDO), acts by releasing Nrf2 from KEAP1,is a highly potent activator of Nrf2 that induce programmed cell death (apoptosis) in cancer cells. | |
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Protocol (from reference)
Selleck's Bardoxolone (CDDO) has been cited by 4 publications
| Complementary gene regulation by NRF1 and NRF2 protects against hepatic cholesterol overload [ Cell Rep, 2023, 42(4):112399] | PubMed: 37060561 |
| KIT Low Cells Mediate Imatinib Resistance in Gastrointestinal Stromal Tumor [ Mol Cancer Ther, 2021, molcanther.0973.2020] | PubMed: 34376580 |
| GLS1 depletion inhibited colorectal cancer proliferation and migration via redox/Nrf2/autophagy-dependent pathway [ Arch Biochem Biophys, 2021, 708:108964] | PubMed: 34119480 |
| Genetic Screens Identify Host Factors for SARS-CoV-2 and Common Cold Coronaviruses [ Cell, 2020, S0092-8674(20)31626-3] | PubMed: 33333024 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.