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Nitrofurantoin

Name: Nitrofurantoin
Brand: Selleck Chemicals
SKU: S4536
Rating: 5 (1 reviews)

Synonyms: Macrodantin, Furadantine, Furadonine

Catalog No.S4536 Purity:99.82%

Nitrofurantoin (Macrodantin, Furadantine, Furadonine) is an antibiotic used to treat bladder infections.It inhibits bacterial DNA, RNA, and cell wall protein synthesis.

Nitrofurantoin Chemical Structure

CAS No. 67-20-9

Purity & Quality Control

Batch: S453601 DMSO]47 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.82%

99.82

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Biological Activity

Description	Nitrofurantoin (Macrodantin, Furadantine, Furadonine) is an antibiotic used to treat bladder infections.It inhibits bacterial DNA, RNA, and cell wall protein synthesis.

In vitro
In vitro	Nitrofurantoin is very effective against both outdoor and indoor urinary isolates and can be used empirically for uncomplicated urinary tract infections^[3]. Nitrofurantoin can directly injure lung parenchymal cells, probably through oxidant mechanisms^[2].
Cell Research	Cell lines	HeLa cell
	Concentrations	5, 10, 20, 40 μM
	Incubation Time	24 h
	Method	HeLa cells are grown and infected with T. gondii for 24 hr in a 96-well microplate, and then treated with drugs. After 24 hr, 20 μl of MTS solution is added directly into culture wells, followed by incubating for 1.5 hr at 37˚C and measuring the absorbance at 490 nm in a microplate reader.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-05-22)
NCT05630833	Recruiting	Urinary Tract Infections	GlaxoSmithKline	January 11 2023	Phase 3
NCT05817253	Completed	Clinical Audit\|Quality Improvement	University of British Columbia\|Ministry of Health British Columbia	September 23 2021	Not Applicable
NCT04900571	Completed	Pain Postoperative\|Irreversible Pulpitis	Altamash Institute of Dental Medicine	January 1 2021	Phase 4
NCT02727322	Completed	Pelvic Organ Prolapse	Halina M Zyczynski MD\|University of Pittsburgh	August 2016	Phase 4
NCT00678041	Terminated	Urinary Tract Infections	University of Pittsburgh	May 2008	Not Applicable

References

Chemical Information & Solubility

Molecular Weight	238.16	Formula	C₈H₆N₄O₅
CAS No.	67-20-9	SDF	Download Nitrofurantoin SDF
Smiles	C1C(=O)NC(=O)N1N=CC2=CC=C(O2)[N+](=O)[O-]
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 47 mg/mL ( (197.34 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
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Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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% DMSO + % + % Tween 80 + % ddH₂O

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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