Home Epigenetics Epigenetic Reader Domain inhibitor NI-42 For research use only.

NI-42

Synonyms: compound 13-d

NI-42 is a biased, potent inhibitor of the of the bromodomain and PHD finger-containing (BRPF) with IC50s of 7.9, 48, 260 nM for BRPF1/2/3.

NI-42 Chemical Structure

NI-42 Chemical Structure

CAS No. 1884640-99-6

Purity & Quality Control

Batch: E049401 DMSO]71 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.82%
99.82

NI-42 Related Products

Signaling Pathway

Epigenetic Reader Domain Signaling Pathways

Epigenetic Reader Domain Signaling Pathway

Biological Activity

Description NI-42 is a biased, potent inhibitor of the of the bromodomain and PHD finger-containing (BRPF) with IC50s of 7.9, 48, 260 nM for BRPF1/2/3.
Targets
BRPF1 [1]
(in the BROMOscan assay)		 BRPF2 [1]
(in the BROMOscan assay)		 BRPF3 [1]
(in the BROMOscan assay)
7.9 nM 48 nM 260 nM

Chemical Information & Solubility

Molecular Weight 353.4 Formula

C18H15N3O3S
CAS No. 1884640-99-6 SDF --
Smiles CN1C(=O)C(=CC2=C1C=CC(=C2)N[S](=O)(=O)C3=CC=C(C=C3)C#N)C
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 71 mg/mL ( (200.9 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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