Home Metabolism PPAR agonist Seladelpar For research use only.

Seladelpar

Synonyms: MBX-8025

Seladelpar(MBX-8025) is a potent and selective agonist of peroxisome proliferator–activated receptor-delta (PPAR-δ) with EC50 of 2 nM for human PPAR-δ. MBX-8025 enhances insulin sensitivity, counters dyslipidemia, and reduces hepatic storage of lipotoxic lipids, thereby ameliorating NASH pathology in obese diabetic mice.

Seladelpar Chemical Structure

Seladelpar Chemical Structure

CAS No. 851528-79-5(freebase)

Purity & Quality Control

Seladelpar Related Products

Signaling Pathway

PPAR Signaling Pathways

PPAR Signaling Pathway

Biological Activity

Description Seladelpar(MBX-8025) is a potent and selective agonist of peroxisome proliferator–activated receptor-delta (PPAR-δ) with EC50 of 2 nM for human PPAR-δ. MBX-8025 enhances insulin sensitivity, counters dyslipidemia, and reduces hepatic storage of lipotoxic lipids, thereby ameliorating NASH pathology in obese diabetic mice.
Targets
PPAR-δ [1]
(Cell-free assay)
2 nM(EC50)

Chemical Information & Solubility

Molecular Weight 444.47 Formula

C21H23F3O5S
CAS No. 851528-79-5(freebase) SDF Download Seladelpar SDF
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 89 mg/mL ( (200.23 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 89 mg/mL


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In vivo
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