Home Neuronal Signaling NMDAR antagonist Linalool For research use only.

Linalool

Synonyms: Phantol

Linalool (Phantol), a monoterpene compound commonly found as major component of essential oils of several aromatic species, is a competitive antagonist of NMDA receptors.

Linalool Chemical Structure

Linalool Chemical Structure

CAS No. 78-70-6

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Biological Activity

Description Linalool (Phantol), a monoterpene compound commonly found as major component of essential oils of several aromatic species, is a competitive antagonist of NMDA receptors.
Targets
NMDAR [2]
In vitro
In vitro Linalool exhibits a good cytotoxic effect on U937 and HeLa cells, with the IC50 value of 2.59 and 11.02 μM, respectively. Linalool inhibits the growth of various human cancer cells by causing apoptotic cell death. It can induce the cell cycle of U937 cells to arrest at the G0/G1 phase, while HeLa cells arrest at the G2/M phase, and its function facilitates the expression of p53, p21, p27, p16, and p18 (CDKIs) and the non-expression of CDK activity[3]. Linalool non-selectively suppresses the voltage-gated currents in newt sensory neurons and rat cerebellar Purkinje cells[4].
Cell Research Cell lines U937 cells
Concentrations 1.30, 1.94, 3.24, and 6.48 μM
Incubation Time 24 h
Method

Water-soluble tetrazolium salts (WST-1) analysis is used to determine inhibition of cell growth by varying the concentrations (1.30, 1.94, 3.24, and 6.48 μM) of linalool administered to U937 cells (1.2 × 105/mL) and activating for 24 h.
In Vivo
In vivo Linalool (i.p. 10-200mg/kg; p.o., 5-100mg/kg) shows significant antinociceptive activity against glutamate induced pain in mice, possible due mechanisms operated by ionotropic glutamate receptors, namely AMPA, NMDA and kainate but not via metabotropic receptors. Linalool (50-150mg/kg, s.c.) shows antinociceptive activity in formalin and hot-plate tests. This effect is mediated by NMDA, opioid dopamine D2, muscarinic M2 receptors and KATP channels. Linalool (50 and 100mg/kg doses) impairs long-term memory acquisition, but not short-term memory acquisition, in the object recognition task in rats[1].
Animal Research Animal Models Adult male albino mice
Dosages 50, 75 and 100 mg/kg
Administration i.p.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05858723 Not yet recruiting
Allergic Contact Dermatitis
National Allergy Research Center Denmark
 August 2023 Not Applicable

Chemical Information & Solubility

Molecular Weight 154.25 Formula

C10H18O
CAS No. 78-70-6 SDF --
Density 0.87 g/mL at 25 °C
Smiles CC(=CCCC(C)(C=C)O)C
Storage (From the date of receipt) 2 years -80°C liquid

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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