Linalool

Catalog No.S4957 Batch:S495701

Print

Technical Data

Formula

C10H18O
Molecular Weight 154.25 CAS No. 78-70-6
Solubility (25°C)* In vitro  
 
 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Biological Activity

Description Linalool (Phantol), a monoterpene compound commonly found as major component of essential oils of several aromatic species, is a competitive antagonist of NMDA receptors.
Targets
NMDAR [2]
In vitro Linalool exhibits a good cytotoxic effect on U937 and HeLa cells, with the IC50 value of 2.59 and 11.02 μM, respectively. Linalool inhibits the growth of various human cancer cells by causing apoptotic cell death. It can induce the cell cycle of U937 cells to arrest at the G0/G1 phase, while HeLa cells arrest at the G2/M phase, and its function facilitates the expression of p53, p21, p27, p16, and p18 (CDKIs) and the non-expression of CDK activity[3]. Linalool non-selectively suppresses the voltage-gated currents in newt sensory neurons and rat cerebellar Purkinje cells[4].
In vivo Linalool (i.p. 10-200mg/kg; p.o., 5-100mg/kg) shows significant antinociceptive activity against glutamate induced pain in mice, possible due mechanisms operated by ionotropic glutamate receptors, namely AMPA, NMDA and kainate but not via metabotropic receptors. Linalool (50-150mg/kg, s.c.) shows antinociceptive activity in formalin and hot-plate tests. This effect is mediated by NMDA, opioid dopamine D2, muscarinic M2 receptors and KATP channels. Linalool (50 and 100mg/kg doses) impairs long-term memory acquisition, but not short-term memory acquisition, in the object recognition task in rats[1].
Density 0.87 g/mL at 25 °C

Protocol (from reference)

Cell Assay:

[3]
  • Cell lines

    U937 cells

  • Concentrations

    1.30, 1.94, 3.24, and 6.48 μM

  • Incubation Time

    24 h

  • Method

    Water-soluble tetrazolium salts (WST-1) analysis is used to determine inhibition of cell growth by varying the concentrations (1.30, 1.94, 3.24, and 6.48 μM) of linalool administered to U937 cells (1.2 × 105/mL) and activating for 24 h.
Animal Study:

[1]
  • Animal Models

    Adult male albino mice

  • Dosages

    50, 75 and 100 mg/kg

  • Administration

    i.p.

RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.

SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.