Home Neuronal Signaling NMDAR agonist NMDA (N-Methyl-D-aspartic acid) For research use only.

NMDA (N-Methyl-D-aspartic acid)

NMDA（N-Methyl-D-aspartic acid）is a specific agonist for NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor. Phase 4.

NMDA (N-Methyl-D-aspartic acid) Chemical Structure

NMDA (N-Methyl-D-aspartic acid) Chemical Structure

CAS No. 6384-92-5

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NMDA (N-Methyl-D-aspartic acid) Related Products

Biological Activity

Description NMDA（N-Methyl-D-aspartic acid）is a specific agonist for NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor. Phase 4.
Targets
NMDA receptor [1]
In vitro
In vitro NMDA is an excitatory amino acid neurotransmitter, which only binds to the NMDA receptor without effecting other glutamate receptors (such as those for AMPA and kainate). NMDA specifically binds to the NR2 subunits of NMDA receptor, and then stimulates the open of non-specific cation channel which can allow the passage of Ca2+ and Na+ into the cell and K+ out of the cell. Activation of the NMDA receptor is able to produce the excitatory postsynaptic potential (EPSP), and trigger the increase of intracellular Ca2+ content which may further take participating in various signaling pathways. NMDA receptor plays a key role in a wide range of physiological (e.g. long-term potentiation and neuronal plasticity) and pathological processes (e.g. excitotoxicity and epilepsy). [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06236451 Recruiting
Schizophrenia
All India Institute of Medical Sciences Bhubaneswar
 April 5 2024 Phase 4
NCT06185790 Recruiting
Mitochondrial Diseases|Diabetes-Deafness Syndrome Maternally Transmitted
Radboud University Medical Center|Stichting Stofwisselkracht
 January 5 2024 Not Applicable
NCT05954468 Recruiting
NMDAR Antibody-associated Auto-immune Encephalitis
Hospices Civils de Lyon
 October 9 2023 --
NCT06183788 Recruiting
Anti-NMDA Receptor Encephalitis
Fundacion Clinic per a la Recerca Biomédica|Hospital Sant Joan de Deu
 January 16 2023 Not Applicable
NCT05650229 Active not recruiting
Primary Mitochondrial Disease
Abliva AB
 December 13 2022 Phase 2

Chemical Information & Solubility

Molecular Weight 147.13 Formula

C5H9NO4
CAS No. 6384-92-5 SDF Download NMDA (N-Methyl-D-aspartic acid) SDF
Smiles CNC(CC(=O)O)C(=O)O
Storage (From the date of receipt)

In vitro
Batch:

Water : 29 mg/mL

DMSO : 15 mg/mL ( (101.95 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


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In vivo
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