NMDA (N-Methyl-D-aspartic acid)

Catalog No.S7072 Batch:S707203

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Technical Data

Formula

C5H9NO4
Molecular Weight 147.13 CAS No. 6384-92-5
Solubility (25°C)* In vitro Water 29 mg/mL (197.1 mM)
DMSO 15 mg/mL (101.95 mM)
Ethanol Insoluble
In vivo (Add solvents to the product individually and in order)
5% DMSO 95% Corn oil
0.75mg/ml
5%DMSO 40%PEG300 5%Tween80 50%ddH2O
0.75mg/ml
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description NMDA（N-Methyl-D-aspartic acid）is a specific agonist for NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor. Phase 4.
Targets
NMDA receptor [1]
In vitro NMDA is an excitatory amino acid neurotransmitter, which only binds to the NMDA receptor without effecting other glutamate receptors (such as those for AMPA and kainate). NMDA specifically binds to the NR2 subunits of NMDA receptor, and then stimulates the open of non-specific cation channel which can allow the passage of Ca2+ and Na+ into the cell and K+ out of the cell. Activation of the NMDA receptor is able to produce the excitatory postsynaptic potential (EPSP), and trigger the increase of intracellular Ca2+ content which may further take participating in various signaling pathways. NMDA receptor plays a key role in a wide range of physiological (e.g. long-term potentiation and neuronal plasticity) and pathological processes (e.g. excitotoxicity and epilepsy). [1]

Protocol (from reference)

Selleck's NMDA (N-Methyl-D-aspartic acid) has been cited by 8 publications

Overexpression of EphB2 in the basolateral amygdala is crucial for inducing visceral pain sensitization in rats subjected to water avoidance stress [ CNS Neurosci Ther, 2024, 30(2):e14611] PubMed: 38353051
The role and mechanism of esketamine in preventing and treating remifentanil-induced hyperalgesia based on the NMDA receptor-CaMKII pathway [ Open Life Sci, 2024, 19(1):20220816] PubMed: 38314140
Sevoflurane upregulates neuron death process-related Ddit4 expression by NMDAR in the hippocampus [ Aging -Albany NY), 2023, 15(12):5698-5712] PubMed: 37348034
Sevoflurane upregulates neuron death process-related Ddit4 expression by NMDAR in the hippocampus [ Aging (Albany NY), 2023, 15(12):5698-5712] PubMed: 37348034
Magnesium Oxide/Poly (L-lactide-co-ε-caprolactone) Scaffolds Loaded with Neural Morphogens Promote Spinal Cord Repair through Targeting the Calcium Influx and Neuronal Differentiation of Neural Stem Cells [ Adv Healthc Mater, 2022, e2200386] PubMed: 35587044
Activation of NMDA receptors in brain endothelial cells increases transcellular permeability [ Fluids Barriers CNS, 2022, 19(1):70] PubMed: 36068542
N-Methyl D-aspartate receptor subtype 2B/Ca2+/calmodulin-dependent protein kinase II signaling in the lateral habenula regulates orofacial allodynia and anxiety-like behaviors in a mouse model of trigeminal neuralgia [ Front Cell Neurosci, 2022, 16:981190] PubMed: 36187288
NMDA receptor antagonists attenuate intrathecal morphine-induced pruritus through ERK phosphorylation. [ Mol Brain, 2018, 11(1):35] PubMed: 29954440

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

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