Home Neuronal Signaling NMDAR antagonist Memantine HCl For research use only.

Memantine HCl

Memantine HCl is an antagonist of NMDAR. It is also a CYP2B6 and CYP2D6 inhibitor for recombinant CYP2B6 and CYP2D6 with IC50 of 1.12 μM and 242.4 μM, Ki of 0.51 μM and 84.4 μM, respectively.

Memantine HCl Chemical Structure

Memantine HCl Chemical Structure

CAS No. 41100-52-1

Purity & Quality Control

Memantine HCl Related Products

Biological Activity

Description Memantine HCl is an antagonist of NMDAR. It is also a CYP2B6 and CYP2D6 inhibitor for recombinant CYP2B6 and CYP2D6 with IC50 of 1.12 μM and 242.4 μM, Ki of 0.51 μM and 84.4 μM, respectively.
Targets
NMDAR [1] CYP2B6 [2]
(Cell-free assay)		 CYP2B6 [2]
(Cell-free assay)		 CYP2D6 [2]
(Cell-free assay)		 CYP2D6 [1]
(Cell-free assay)
0.51 μM(Ki) 1.12 μM 84.4 μM(Ki) 242.4 μM
In vitro
In vitro

Memantine inhibits CYP2B6 and CYP2D6 activities with Ki of 76.7 and 94.9 µM, respectively, in human liver microsomes.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06275035 Recruiting
Neurocognitive Dysfunction
Tata Memorial Centre
 February 22 2024 Phase 3
NCT05804279 Completed
Healthy
Hyundai Pharm
 December 28 2022 Phase 1
NCT05063851 Recruiting
Alzheimer Disease
University of Virginia
 October 11 2021 Phase 2
NCT05015595 Unknown status
Obsessive-Compulsive Disorder
University of Roma La Sapienza
 September 1 2021 Phase 3

Chemical Information & Solubility

Molecular Weight 215.76 Formula

C12H21N.HCl
CAS No. 41100-52-1 SDF Download Memantine HCl SDF
Smiles CC12CC3CC(C1)(CC(C3)(C2)N)C.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 43 mg/mL ( (199.29 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 43 mg/mL

Ethanol : 43 mg/mL


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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