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Spermidine trihydrochloride NMDAR antagonist

Name: Spermidine trihydrochloride
Brand: Selleck Chemicals
SKU: S3653
Availability: InStock
Rating: 5 (3 reviews)

Cat.No.S3653

Spermidine (4-Azaoctamethylenediamine), a natural polyamine produced from putrescine and decarboxylated S-adenosylmethionine (dcSAM) by spermidine synthase, is a novel autophagy inducer and negatively modulates N-methyl-d-aspartate (NMDA).

Chemical Structure

Molecular Weight: 254.63

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Quality Control

Batch: Purity: 98.54%

98.54

Related Targets	Adrenergic Receptor AChR 5-HT Receptor COX Calcium Channel Histamine Receptor Dopamine Receptor GABA Receptor TRP Channel Cholinesterase (ChE)
Other NMDAR Inhibitors	(+)-Dizocilpine (MK 801) Maleate (-)-Dizocilpine (MK 801) Maleate NMDA (N-Methyl-D-aspartic acid) Ifenprodil Tartrate Memantine HCl Kynurenic acid Mephenesin Quinolinic acid Radiprodil (RGH-896) NMDAR antagonist 1

Solubility

In vitro
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Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
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In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	254.63	Formula	C₇H₁₉N₃.3HCl	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	334-50-9	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	4-Azaoctamethylenediamine trihydrochloride			Smiles	C(CCNCCCN)CN.Cl.Cl.Cl

Mechanism of Action

Targets/IC₅₀/Ki	Autophagy NMDAR
In vitro	Spermidine induces autophagy in cultured yeast and mammalian cells, as well as in nematodes and flies.
In vivo	Spermidine at 200 μg/mouse, intracerebellar injection (icb), does not alter basal cGMP levels. Spermidine attenuates responses mediated through the N-methyl-D-aspartate (NMDA), NMDA-associated glycine receptor and quisqualate receptors. Spermidine is widely distributed in neural and non-neural tissues and has been shown to play a key role in cell differentiation and growth.
References	[1] https://pubmed.ncbi.nlm.nih.gov/20110777/ [2] https://pubmed.ncbi.nlm.nih.gov/20504558/

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