Home Neuronal Signaling NMDAR antagonist Radiprodil (RGH-896) For research use only.

Radiprodil (RGH-896)

Radiprodil (RGH-896) is a NR2B-selective NMDA receptor antagonist, initially developed for the treatment of neuropathic pain.

Radiprodil (RGH-896) Chemical Structure

Radiprodil (RGH-896) Chemical Structure

CAS No. 496054-87-6

Purity & Quality Control

Batch: S664401 DMSO]79 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.7%
99.7

Radiprodil (RGH-896) Related Products

Biological Activity

Description Radiprodil (RGH-896) is a NR2B-selective NMDA receptor antagonist, initially developed for the treatment of neuropathic pain.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06392009 Recruiting
Tuberous Sclerosis Complex|Focal Cortical Dysplasia
GRIN Therapeutics Inc.
 May 2024 Phase 1|Phase 2
NCT05818943 Recruiting
GRIN-related Disorders
GRIN Therapeutics Inc.
 March 7 2023 Phase 1
NCT02829827 Terminated
Infantile Spasms (IS)
UCB Biopharma S.P.R.L.|UCB Pharma
 December 4 2017 Phase 2
NCT02647697 Completed
Healthy Volunteers
UCB Biopharma S.P.R.L.|PRA Health Sciences|UCB Pharma
 January 2016 Phase 1

Chemical Information & Solubility

Molecular Weight 397.40 Formula

C21H20FN3O4
CAS No. 496054-87-6 SDF --
Smiles C1CN(CCC1CC2=CC=C(C=C2)F)C(=O)C(=O)NC3=CC4=C(C=C3)NC(=O)O4
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 79 mg/mL ( (198.79 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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