Home Epigenetics Epigenetic Reader Domain inhibitor E-7386 For research use only.

E-7386

E-7386 is a selective inhibitor which inhibits interaction between CBP/beta-catenin with IC50 value of 0.0484 μM in HEK293 cells.

E-7386 Chemical Structure

E-7386 Chemical Structure

CAS No. 1799824-08-0

Purity & Quality Control

Batch: E134801 DMSO]100 mg/mL]false]Ethanol]100 mg/mL]false]Water]Insoluble]false Purity: 99.32%
99.32

E-7386 Related Products

Signaling Pathway

Epigenetic Reader Domain Signaling Pathways

Epigenetic Reader Domain Signaling Pathway

Biological Activity

Description E-7386 is a selective inhibitor which inhibits interaction between CBP/beta-catenin with IC50 value of 0.0484 μM in HEK293 cells.
Targets
CBP/beta-catenin [1]
0.0484 μM
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05607537 Completed
Healthy Volunteers
Eisai Limited|Eisai Inc.
 October 17 2022 Phase 1
NCT05091346 Recruiting
Melanoma|Carcinoma Hepatocellular|Colorectal Neoplasms
Eisai Inc.|Merck Sharp & Dohme LLC
 October 27 2021 Phase 1|Phase 2
NCT04840927 Withdrawn
Healthy Volunteers
Eisai Limited|Eisai Inc.
 April 9 2021 Phase 1
NCT04008797 Recruiting
Neoplasms|Carcinoma Hepatocellular|Liver Neoplasms|Colorectal Neoplasms|Endometrial Neoplasms
Eisai Inc.
 July 11 2019 Phase 1
NCT03996226 Completed
Food Effect in Healthy Participants
Eisai Inc.
 June 7 2019 Phase 1
NCT03833700 Active not recruiting
Solid Neoplasms|Colorectal Neoplasms|Gastrointestinal Tumors
Eisai Co. Ltd.|Eisai Inc.
 March 5 2019 Phase 1

Chemical Information & Solubility

Molecular Weight 725.86 Formula

C39H48FN9O4
CAS No. 1799824-08-0 SDF --
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (137.76 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 100 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy E-7386 | E-7386 supplier | purchase E-7386 | E-7386 cost | E-7386 manufacturer | order E-7386 | E-7386 distributor