Dupilumab (anti-IL-4Rα)

Synonyms: REGN-668, SAR-231893

Catalog No.A2038 Purity:99.32%

Dupilumab (anti-IL-4Rα) is a fully human anti–interleukin-4 receptor α monoclonal antibody that inhibits both interleukin-4 (IL-4) and interleukin-13 (IL-13) signaling through blockade of the shared IL-4α subunit.

Click to purchase the isotype control of Dupilumab (anti-IL-4Rα)

Selleck's Dupilumab (anti-IL-4Rα) has been cited by 1 publication

Purity & Quality Control

Batch: Purity: 99.32% Protein concentration: 5.72 mg/ml Endotoxin Level: <1 EU/mg

99.32

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1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Biological Activity

Description	Dupilumab (anti-IL-4Rα) is a fully human anti–interleukin-4 receptor α monoclonal antibody that inhibits both interleukin-4 (IL-4) and interleukin-13 (IL-13) signaling through blockade of the shared IL-4α subunit.

References
[1] Mario Castro, et al. N Engl J Med . 2018 Jun 28;378(26):2486-2496. [2] Melinda J Gooderham, et al. J Am Acad Dermatol . 2018 Mar;78(3 Suppl 1):S28-S36.

References

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

Product Details

CAS No.	1190264-60-8
Molecular Weight	147 KD
Isotype	Human IgG4, κ
Source	CHO cells
Sterility	0.2 μM filtered
Formulation	100 mM Pro-Ac, 20 mM Arg, pH5.0
Storage (From the date of receipt)	Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

^*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

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