Dupilumab (anti-IL-4Rα)

Catalog No.A2038 Batch: A203803

Technical Data

CAS No.	1190264-60-8
Formulation	100 mM Pro-Ac, 20 mM Arg, pH5.0
Isotype	Human IgG4, κ
Source	CHO cells
Storage (From the date of receipt)	Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles.
Purity	99%
Protein concentration	6.9mg/ml
Endotoxin Level	＜1EU/mg

Biological Activity

Description	Dupilumab (anti-IL-4Rα) is a fully human anti–interleukin-4 receptor α monoclonal antibody that inhibits both interleukin-4 (IL-4) and interleukin-13 (IL-13) signaling through blockade of the shared IL-4α subunit.

References	[1] Mario Castro, et al. N Engl J Med . 2018 Jun 28;378(26):2486-2496. [2] Melinda J Gooderham, et al. J Am Acad Dermatol . 2018 Mar;78(3 Suppl 1):S28-S36.

References

Selleck's Dupilumab (anti-IL-4Rα) has been cited by 1 publication

Macrophage-derived chemokine CCL22 establishes local LN-mediated adaptive thermogenesis and energy expenditure [ Sci Adv, 2024, 10(26):eadn5229]	PubMed: 38924414

Macrophage-derived chemokine CCL22 establishes local LN-mediated adaptive thermogenesis and energy expenditure [ Sci Adv, 2024, 10(26):eadn5229]

PubMed: 38924414

FOR RESEARCH USE ONLY. NOT FOR USE IN HUMANS.

Specific storage and handling information for each product is indicated on the product datasheet. Most Selleck products are stable under the recommended conditions. Products are sometimes shipped at a temperature that differs from the recommended storage temperature. Short-term storage of many products are stable in the short-term at temperatures that differ from that required for long-term storage.
We ensure that the product is shipped under conditions that will maintain the quality of the reagents. Upon receipt of the product, follow the storage recommendations on the product data sheet.