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Dehydroabietic acid

Name: Dehydroabietic acid
Brand: Selleck Chemicals
SKU: S3226
Rating: 5 (1 reviews)

Synonyms: DAA, DHAA

Catalog No.S3226 Purity:99.45%

Dehydroabietic acid (DAA, DHAA), a naturally occurring diterpene resin acid derived from coniferous plants such as Pinus and Picea, displays anti-inflammatory activity via suppression of Src-, Syk-, and TAK1-mediated pathways.

Dehydroabietic acid Chemical Structure

CAS No. 1740-19-8

Purity & Quality Control

Batch: S322601 DMSO]100 mg/mL]false]]]false]]]false Purity: 99.45%

99.45

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Biological Activity

Description

Targets

Src ^[1]

Syk ^[1]

TAK1 ^[1]

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-05-22)
NCT05506475	Not yet recruiting	HIV Infection\|Hepatitis C Infection	Institut Pasteur\|National Institute of Hygiene and Epidemiology Vietnam\|ANRS Emerging Infectious Diseases	May 2024	--
NCT05521880	Not yet recruiting	Substance Use Disorders\|Infection Soft Tissue\|Bacteremia\|Osteomyelitis Acute\|Septic Arthritis	University of Maryland Baltimore	May 2024	Phase 4
NCT05992077	Recruiting	HCV Infection	ANRS Emerging Infectious Diseases	August 7 2023	Not Applicable
NCT05713136	Not yet recruiting	Hepatitis C	Kirby Institute	August 14 2023	--
NCT05248555	Recruiting	Hepatitis C	Kirby Institute	January 16 2023	--

References

[1] Eunji Kim, et al. Int J Mol Sci. 2019 Mar 29;20(7):1593.

Chemical Information & Solubility

Molecular Weight	300.44	Formula	C₂₀H₂₈O₂
CAS No.	1740-19-8	SDF	--
Smiles	CC(C)C1=CC2=C(C=C1)C3(C)CCCC(C)(C3CC2)C(O)=O
Storage (From the date of receipt)	3 years -20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C powder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 100 mg/mL ( (332.84 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

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Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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