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Dalbavancin

Name: Dalbavancin
Brand: Selleck Chemicals
SKU: S4848
Rating: 5 (3 reviews)

Synonyms: BI 397, MDL 63397

Catalog No.S4848 Purity:98.35%

Dalbavancin is a lipoglycopeptide antibiotic that has bactericidal activity against Gram-positive bacteria including various staphylococci.

Dalbavancin Chemical Structure

CAS No. 171500-79-1

Purity & Quality Control

Batch: Purity: 98.35%

98.35

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Biological Activity

Description	Dalbavancin is a lipoglycopeptide antibiotic that has bactericidal activity against Gram-positive bacteria including various staphylococci.

In vitro
In vitro	Dalbavancin's mechanism of action involves the formation of a complex with the C-terminal d-alanyl-d-alanine of growing peptidoglycan chains, thereby inhibiting bacterial cell wall biosynthesis. In addition, dalbavancin appears to have the unique ability to dimerise and anchor its lipophilic side chain in the bacterial membranes. Dalbavancin possesses more potent in vitro bactericidal activity than vancomycin or teicoplanin against many resistant Gram-positive organisms^[1].

In Vivo
In vivo	Dalbavancin has a half-life of 170-210 h in human. It exhibits linear, dose-dependent pharmacokinetics in healthy adults, following the administration of single intravenous doses of dalbavancin 140-1120 mg. Total protein binding of dalbavancin is concentration independent, reversible and estimated to be 93%. Animal studies regarding tissue distribution have demonstrated tissue concentrations reaching maximal levels within 24 h, with the highest concentrations in the liver and kidneys^[1].

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-05-22)
NCT05046860	Recruiting	Osteoarticular Infection	Centre Hospitalier Universitaire de Nice	March 7 2022	Not Applicable
NCT04959799	Completed	Diabetes\|Infection	Aziende Chimiche Riunite Angelini Francesco S.p.A\|Iqvia Pty Ltd	January 2 2022	--
NCT04485676	Completed	Skin Diseases Bacterial\|Skin Diseases Infectious	Angelini Farmacéutica\|Effice Servicios Para la Investigacion S.L.	July 15 2020	--
NCT06089044	Completed	Prosthesis-related Infections	Tourcoing Hospital	January 1 2020	--
NCT03696901	Terminated	Bacterial Infections	Correvio International Sarl\|AMS Advanced Medical Services GmbH\|PrimeVigilance\|Advanz Pharma	November 21 2018	--

References

[1] A Y Chen, et al. Int J Clin Pract. 2007, 61(5): 853-863.

Chemical Information & Solubility

Molecular Weight	1816.69	Formula	C₈₈H₁₀₀Cl₂N₁₀O₂₈
CAS No.	171500-79-1	SDF	--
Smiles	CNC1C(=O)NC2CC3=CC=C(OC4=C(OC5OC(C(O)C(O)C5NC(=O)CCCCCCCCC(C)C)C(O)=O)C6=CC(=C4)C(NC(=O)C(NC2=O)C7=CC(=CC(=C7Cl)O)OC8=CC=C1C=C8O)C(=O)NC9C(=O)NC(C(O)C%10=CC(=C(O6)C=C%10)Cl)C(=O)NC(C(=O)NCCCN(C)C)C%11
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 100 mg/mL ( (55.04 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 100 mg/mL

Ethanol : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
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Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
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