Home Metabolism PPAR agonist Choline Fenofibrate For research use only.

Choline Fenofibrate

Synonyms: ABT-335

Choline fenofibrate(ABT-335) is a newly developed choline salt of fenofibric acid, a synthetic phenoxy-isobutyric acid derivate with antihyperlipidemic activity that acts as an PPARα agonist.

Choline Fenofibrate Chemical Structure

Choline Fenofibrate Chemical Structure

CAS No. 856676-23-8

Purity & Quality Control

Batch: S581201 Water]9 mg/mL]false]Ethanol]7 mg/mL]false]DMSO]5 mg/mL]false Purity: 99.97%
99.97

Choline Fenofibrate Related Products

Signaling Pathway

PPAR Signaling Pathways

PPAR Signaling Pathway

Biological Activity

Description Choline fenofibrate(ABT-335) is a newly developed choline salt of fenofibric acid, a synthetic phenoxy-isobutyric acid derivate with antihyperlipidemic activity that acts as an PPARα agonist.
In vitro
In vitro

WAY-316606 enhances hair shaft production, hair shaft keratin expression, and inhibits spontaneous HF regression (catagen) ex vivo. WAY-316606 effectively enhances β-catenin activity in mammalian skin cell populations, namely in both human hair pre-cortex keratinocytes and DP fibroblasts ex vivo[1].
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00839293 Completed
Healthy
Abbott
 February 2009 Phase 1
NCT00808678 Completed
Healthy
AstraZeneca
 December 2008 Phase 1
NCT00826358 Completed
Healthy
AstraZeneca
 November 2008 Phase 1
NCT00585143 Completed
Dyslipidemia Renal Insufficiency
AstraZeneca
 January 2008 Phase 1

Chemical Information & Solubility

Molecular Weight 421.91 Formula

C22H28ClNO5
CAS No. 856676-23-8 SDF --
Smiles CC(C)(C(=O)[O-])OC1=CC=C(C=C1)C(=O)C2=CC=C(C=C2)Cl.C[N+](C)(C)CCO
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

Water : 9 mg/mL

Ethanol : 7 mg/mL

DMSO : 5 mg/mL ( (11.85 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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