Home Neuronal Signaling Dopamine Receptor antagonist - 5-HT Receptor antagonist - Sodium Channel inhibitor - Potassium Channel inhibitor Chlorpromazine For research use only.

Chlorpromazine

Synonyms: CPZ

Chlorpromazine (CPZ) is a low-potency typical antipsychotic agent that is used to treat psychotic disorders such as schizophrenia. Chlorpromazine (CPZ) inhibits 5-HT(2A) receptor and dopamine D2 in vitro. Chlorpromazine (CPZ) also inhibits sodium channel and blocks HERG potassium channels with IC50 of 21.6 μM.

Chlorpromazine Chemical Structure

Chlorpromazine Chemical Structure

CAS No. 50-53-3

Purity & Quality Control

Chlorpromazine Related Products

Signaling Pathway

Dopamine Receptor Signaling Pathways

Dopamine Receptor Signaling Pathway

Biological Activity

Description Chlorpromazine (CPZ) is a low-potency typical antipsychotic agent that is used to treat psychotic disorders such as schizophrenia. Chlorpromazine (CPZ) inhibits 5-HT(2A) receptor and dopamine D2 in vitro. Chlorpromazine (CPZ) also inhibits sodium channel and blocks HERG potassium channels with IC50 of 21.6 μM.
In vitro
In vitro

Chlorpromazine exerts a mild decrease in sEV uptake in only one MM cell line, indicating that the uptake of BMSC-derived sEVs by suspension MM cells may not rely on chlorpromazine-targeted receptors.[1]
Cell Research Cell lines MM1S cells, RPMI 8226, U266, H929 cells
Concentrations 5, 10, 20 μM
Incubation Time 30 min for MM1S cells, 4.5 h for RPMI 8226, U266, H929 cells
Method

MM1S cells pre-treated with heparin, cytochalasin D (Cyto D), dynasore, genistein, or chlorpromazine (CPZ) at the indicated concentrations for 30 min are cultured with 50 μg/mL DID-labeled BMSC-derived sEVs for another 4 h. The mean fluorescence intensity of DID in these cells is determined using flow cytometry. RPMI 8226, U266, or H929 cells are treated with heparin, Cyto D, dynasore, genistein, or CPZ at the indicated concentration for 4.5 h in the absence of sEVs and their cell viability is measured.
In Vivo
In vivo

Chlorpromazine suppresses the growth of endometrial cancer (EC) tumors in vivo at a low dose with no signs of toxicity.[2]
Animal Research Animal Models female BALB/c nude mice
Dosages 3 or 12 mg/kg
Administration i.p.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06238089 Recruiting
Intellectual Disability
University of Plymouth|Peninsula Clinical Trials Unit
 December 19 2023 --
NCT05206747 Recruiting
Mania|Sleep|Bipolar Disorder
Ottawa Hospital Research Institute
 September 7 2022 Not Applicable
NCT03548714 Completed
Alcohol Dependence|Alcohol Interaction
Pop Test Oncology LLC|Pharmacotherapies for Alcohol and Substance Use Disorders Alliance|Congressionally Directed Medical Research Programs|Michael E. DeBakey VA Medical Center|Baylor College of Medicine|University of California San Diego
 September 1 2018 Phase 1

Chemical Information & Solubility

Molecular Weight 318.86 Formula

C17H19ClN2S
CAS No. 50-53-3 SDF --
Smiles CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 64 mg/mL ( (200.71 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 64 mg/mL

Water : Insoluble


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In vivo
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