Home Epigenetics Epigenetic Reader Domain chemical CFT8634 For research use only.

CFT8634

CFT8634 is a potent BRD9 degrader with DC50 of 3 nM. It forms a ternary complex with BRD9 and an E3 ligase, resulting in BRD9 ubiquitination. CFT8634 is used in the treatment of SMARCB1-perturbed cancers.

CFT8634 Chemical Structure

CFT8634 Chemical Structure

CAS No. 2704617-96-7

Purity & Quality Control

Batch: E117701 DMSO]100 mg/mL]false]Water]100 mg/mL]false]Ethanol]100 mg/mL]false Purity: 98.7%
98.7

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Signaling Pathway

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Epigenetic Reader Domain Signaling Pathway

Biological Activity

Description CFT8634 is a potent BRD9 degrader with DC50 of 3 nM. It forms a ternary complex with BRD9 and an E3 ligase, resulting in BRD9 ubiquitination. CFT8634 is used in the treatment of SMARCB1-perturbed cancers.
Targets
BRD9 [1]
3 nM(DC50)
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05355753 Terminated
Synovial Sarcoma|Soft Tissue Sarcoma
C4 Therapeutics Inc.
 March 25 2022 Phase 1|Phase 2

Chemical Information & Solubility

Molecular Weight 710.79 Formula

C37H45F3N6O5
CAS No. 2704617-96-7 SDF --
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (140.68 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 100 mg/mL

Ethanol : 100 mg/mL


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In vivo
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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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