Home Microbiology Anti-infection inhibitor AFN-1252 For research use only.

AFN-1252

Synonyms: Debio 1452

AFN-1252 (Debio 1452) is a potent inhibitor of enoyl-acyl carrier protein reductase (FabI), inhibits all clinical isolates of Staphylococcus aureus and Staphylococcus epidermidis at concentrations of ≤0.12 μg/ml.

AFN-1252 Chemical Structure

AFN-1252 Chemical Structure

CAS No. 620175-39-5

Purity & Quality Control

Batch: E112601 DMSO]9 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.4%
99.4

AFN-1252 Related Products

Biological Activity

Description AFN-1252 (Debio 1452) is a potent inhibitor of enoyl-acyl carrier protein reductase (FabI), inhibits all clinical isolates of Staphylococcus aureus and Staphylococcus epidermidis at concentrations of ≤0.12 μg/ml.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03209648 Completed
Healthy Participants
Debiopharm International SA
 June 14 2017 Phase 1
NCT02726438 Completed
Bone Diseases Infectious
Debiopharm International SA
 April 2016 Phase 1

Chemical Information & Solubility

Molecular Weight 375.42 Formula

C22H21N3O3
CAS No. 620175-39-5 SDF --
Smiles CN(CC1=C(C)C2=C(O1)C=CC=C2)C(=O)/C=C/C3=CC4=C(NC(=O)CC4)N=C3
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 9 mg/mL ( (23.97 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

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Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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