Home Proteases Serine Protease inhibitor UK-371804 HCl For research use only.

UK-371804 HCl

UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin).

UK-371804 HCl Chemical Structure

UK-371804 HCl Chemical Structure

CAS No. 256476-36-5

Purity & Quality Control

UK-371804 HCl Related Products

Biological Activity

Description UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin).
Targets
uPA [1]
(Cell-free assay)
10 nM(Ki)
In vitro
In vitro In Vitro, UK-3718046 is able to inhibit exogenous uPA in human chronic wound fluid (IC50=0.89 µM)[1].
In Vivo
In vivo In Vivo, in a porcine acute excisional wound model, following topical delivery, UK-3718046 is able to penetrate into pig wounds and inhibit exogenous uPA activity with no adverse effect on wound healing parameters[1].
Animal Research Animal Models A porcine acute excisional wound model
Dosages 10 mg/mL
Administration topical delivery
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06349590 Not yet recruiting
Colorectal Cancer
University of Chicago
 April 2024 Phase 1|Phase 2
NCT05286710 Recruiting
Deep Vein Thrombosis
RenJi Hospital|First People''s Hospital of Hangzhou|The First Affiliated Hospital with Nanjing Medical University|Affiliated Hospital of Nantong University|Chengdu University of Traditional Chinese Medicine|Second Affiliated Hospital of Suzhou University|Liuzhou Workers Hospital|Shanghai Pudong New Area People''s Hospital|Zhejiang University
 October 26 2022 Not Applicable
NCT05356767 Recruiting
Pharmacomechanical Thrombolysis|Deep Vein Thrombosis
Chengdu University of Traditional Chinese Medicine
 April 1 2022 --
NCT04705766 Recruiting
SARS-CoV Infection|Covid19|Corona Virus Infection|Acute Kidney Injury|Kidney Injury
University of California San Francisco|Rush University Medical Center|University of Michigan|University of California
 March 1 2021 --
NCT04796493 Active not recruiting
Mesenteric Traction Syndrome
Rigshospitalet Denmark
 March 16 2021 --

Chemical Information & Solubility

Molecular Weight 422.29 Formula

C14H16ClN5O4S.HCl
CAS No. 256476-36-5 SDF Download UK-371804 HCl SDF
Smiles CC(C)(C(=O)O)NS(=O)(=O)C1=CC2=C(C=C1)C(=CN=C2N=C(N)N)Cl.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 42 mg/mL ( (99.45 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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