Home PI3K/Akt/mTOR PI3K inhibitor - Sirtuin modulator Quercetin Dihydrate For research use only.

Quercetin Dihydrate

Synonyms: Sophoretin

Quercetin (Sophoretin), a polyphenolic flavonoid found in a wide variety of plant-based foods, such as apples, onions, berries, and red wine, is utilized in many different cultures for their nervous system and anticancer effects. Quercetin (dihydrate), a natural flavonoid, is a stimulator of recombinant SIRT1 and a PI3K inhibitor with IC50s of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively.

Quercetin Dihydrate Chemical Structure

Quercetin Dihydrate Chemical Structure

CAS No. 6151-25-3

Purity & Quality Control

Quercetin Dihydrate Related Products

Signaling Pathway

PI3K Signaling Pathways

PI3K Signaling Pathway

Biological Activity

Description Quercetin (Sophoretin), a polyphenolic flavonoid found in a wide variety of plant-based foods, such as apples, onions, berries, and red wine, is utilized in many different cultures for their nervous system and anticancer effects. Quercetin (dihydrate), a natural flavonoid, is a stimulator of recombinant SIRT1 and a PI3K inhibitor with IC50s of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively.
Targets
SIRT1 [3] PI3Kγ [3]
(Cell-free assay)		 PI3Kδ [3]
(Cell-free assay)		 PI3Kβ [3]
(Cell-free assay)
2.4 μM 3.0 μM 5.4 μM
In vitro
In vitro

Quercetin, a polyphenolic flavonoid found in a wide variety of plant-based foods, such as apples, onions, berries, and red wine, is utilized in many different cultures for their nervous system and anticancer effects. The pharmacological activities of quercetin that modulate antioxidation/oxidation/kinase-signaling pathways might be differentially elicited in neurons compared with malignant cells, ultimately promoting cell survival or death in a cell type- and metabolism-specific manner. Whereas the broad antioxidation and anti-inflammatory activities of quercetin are important for neuronal survival, the oxidative, kinase- and cell cycle-inhibitory, apoptosis-inducing effects of quercetin are essential for its anticancer effects. [1]
In Vivo
In vivo

LD50: Mice 159mg/kg (i.g.) [2]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06003270 Recruiting
Chronic Obstructive Pulmonary Disease|Emphysema|Chronic Bronchitis With Airway Obstruction
Temple University|National Center for Complementary and Integrative Health (NCCIH)|Quercegen Pharmaceuticals
 November 1 2023 Phase 2
NCT04907253 Active not recruiting
Coronary Artery Disease
Montreal Heart Institute
 June 4 2021 Phase 2
NCT04474626 Withdrawn
Sickle Cell Disease|Sickle Cell-Beta0-Thalassemia
Jeffrey Zwicker MD|Quercegen Pharmaceuticals|Dana-Farber Cancer Institute
 December 2020 Phase 2
NCT04063124 Completed
Alzheimer Disease
The University of Texas Health Science Center at San Antonio|Mayo Clinic
 February 14 2020 Phase 1|Phase 2
NCT03989271 Recruiting
Chronic Obstructive Pulmonary Disease
Temple University|National Institutes of Health (NIH)|Quercegen Pharmaceuticals|National Center for Complementary and Integrative Health (NCCIH)
 October 1 2019 Phase 1|Phase 2

Chemical Information & Solubility

Molecular Weight 338.27 Formula

C15H10O7.2H2O
CAS No. 6151-25-3 SDF Download Quercetin Dihydrate SDF
Smiles C1=CC(=C(C=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O)O.O.O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 67 mg/mL ( (198.06 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 17 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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