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MK-2206 2HCl
MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM in cell-free assays, respectively; no inhibitory activities against 250 other protein kinases observed. MK-2206 2HCl induces autophagy and apoptosis in cancer cells. Phase 2.
MK-2206 2HCl Chemical Structure
CAS No. 1032350-13-2
Purity & Quality Control
Batch:
Purity:
99.98%
99.98
MK-2206 2HCl Related Products
| Related Targets | Akt1 Akt2 Akt3 | Click to Expand |
|---|---|---|
| Related Products | Perifosine SC79 Capivasertib (AZD5363) GSK690693 Ipatasertib (GDC-0068) Triciribine (API-2) CCT128930 Afuresertib (GSK2110183) A-674563 HCl AT7867 Oridonin Akti-1/2 PHT-427 Miransertib (ARQ 092) HCl AT13148 Uprosertib (GSK2141795) Miransertib (ARQ-092) SC66 Deguelin ML-9 HCl | Click to Expand |
| Related Compound Libraries | Kinase Inhibitor Library PI3K/Akt Inhibitor Library Apoptosis Compound Library Cell Cycle compound library NF-κB Signaling Compound Library | Click to Expand |
Signaling Pathway
Cell Data
| Cell Lines | Assay Type | Concentration | Incubation Time | Formulation | Activity Description | PMID |
|---|---|---|---|---|---|---|
| NCI-H1650 | Growth Inhibition Assay | IC50=22.764 μM | SANGER | |||
| AM-38 | Growth Inhibition Assay | IC50=22.8689 μM | SANGER | |||
| NCI-H2405 | Growth Inhibition Assay | IC50=23.2533 μM | SANGER | |||
| M14 | Growth Inhibition Assay | IC50=23.4088 μM | SANGER | |||
| ES4 | Growth Inhibition Assay | IC50=23.4232 μM | SANGER | |||
| DJM-1 | Growth Inhibition Assay | IC50=23.5234 μM | SANGER | |||
| S-117 | Growth Inhibition Assay | IC50=23.7651 μM | SANGER | |||
| MZ2-MEL | Growth Inhibition Assay | IC50=23.7759 μM | SANGER | |||
| SK-MEL-2 | Growth Inhibition Assay | IC50=23.8133 μM | SANGER | |||
| HCC1806 | Growth Inhibition Assay | IC50=23.8709 μM | SANGER | |||
| NMC-G1 | Growth Inhibition Assay | IC50=24.2226 μM | SANGER | |||
| DK-MG | Growth Inhibition Assay | IC50=24.294 μM | SANGER | |||
| SK-N-FI | Growth Inhibition Assay | IC50=24.3302 μM | SANGER | |||
| KINGS-1 | Growth Inhibition Assay | IC50=24.4874 μM | SANGER | |||
| HCC2998 | Growth Inhibition Assay | IC50=24.4885 μM | SANGER | |||
| ALL-PO | Growth Inhibition Assay | IC50=24.619 μM | SANGER | |||
| MPP-89 | Growth Inhibition Assay | IC50=25.0458 μM | SANGER | |||
| NCI-H2342 | Growth Inhibition Assay | IC50=25.1953 μM | SANGER | |||
| TE-1 | Growth Inhibition Assay | IC50=25.3563 μM | SANGER | |||
| RH-18 | Growth Inhibition Assay | IC50=25.5918 μM | SANGER | |||
| HT-1376 | Growth Inhibition Assay | IC50=25.6465 μM | SANGER | |||
| U-2-OS | Growth Inhibition Assay | IC50=25.6888 μM | SANGER | |||
| BT-549 | Growth Inhibition Assay | IC50=25.9011 μM | SANGER | |||
| NCI-H1755 | Growth Inhibition Assay | IC50=25.9945 μM | SANGER | |||
| EW-13 | Growth Inhibition Assay | IC50=26.0274 μM | SANGER | |||
| NB13 | Growth Inhibition Assay | IC50=26.0949 μM | SANGER | |||
| NUGC-3 | Growth Inhibition Assay | IC50=26.2103 μM | SANGER | |||
| GMS-10 | Growth Inhibition Assay | IC50=26.2353 μM | SANGER | |||
| CHP-134 | Growth Inhibition Assay | IC50=26.3867 μM | SANGER | |||
| SW962 | Growth Inhibition Assay | IC50=26.5021 μM | SANGER | |||
| SNU-449 | Growth Inhibition Assay | IC50=27.0803 μM | SANGER | |||
| HuP-T4 | Growth Inhibition Assay | IC50=27.0879 μM | SANGER | |||
| SW948 | Growth Inhibition Assay | IC50=27.1344 μM | SANGER | |||
| NCI-H226 | Growth Inhibition Assay | IC50=27.4578 μM | SANGER | |||
| SK-PN-DW | Growth Inhibition Assay | IC50=27.6012 μM | SANGER | |||
| GI-1 | Growth Inhibition Assay | IC50=27.721 μM | SANGER | |||
| CAL-12T | Growth Inhibition Assay | IC50=28.1112 μM | SANGER | |||
| YAPC | Growth Inhibition Assay | IC50=28.2564 μM | SANGER | |||
| SNU-C2B | Growth Inhibition Assay | IC50=28.2964 μM | SANGER | |||
| RCC10RGB | Growth Inhibition Assay | IC50=28.5417 μM | SANGER | |||
| ES7 | Growth Inhibition Assay | IC50=29.1465 μM | SANGER | |||
| PANC-03-27 | Growth Inhibition Assay | IC50=29.444 μM | SANGER | |||
| ES6 | Growth Inhibition Assay | IC50=29.8157 μM | SANGER | |||
| HT-1197 | Growth Inhibition Assay | IC50=30.0598 μM | SANGER | |||
| ZR-75-30 | Growth Inhibition Assay | IC50=30.2383 μM | SANGER | |||
| DB | Growth Inhibition Assay | IC50=30.4942 μM | SANGER | |||
| OCI-AML2 | Growth Inhibition Assay | IC50=31.069 μM | SANGER | |||
| NCI-H2170 | Growth Inhibition Assay | IC50=31.8516 μM | SANGER | |||
| IST-MES1 | Growth Inhibition Assay | IC50=32.2897 μM | SANGER | |||
| 769-P | Growth Inhibition Assay | IC50=32.3641 μM | SANGER | |||
| COR-L23 | Growth Inhibition Assay | IC50=32.9073 μM | SANGER | |||
| SW626 | Growth Inhibition Assay | IC50=33.1776 μM | SANGER | |||
| LU-139 | Growth Inhibition Assay | IC50=33.6605 μM | SANGER | |||
| HT-144 | Growth Inhibition Assay | IC50=33.863 μM | SANGER | |||
| CaR-1 | Growth Inhibition Assay | IC50=33.9822 μM | SANGER | |||
| OE33 | Growth Inhibition Assay | IC50=34.2855 μM | SANGER | |||
| COLO-800 | Growth Inhibition Assay | IC50=34.3647 μM | SANGER | |||
| NB14 | Growth Inhibition Assay | IC50=34.4684 μM | SANGER | |||
| KURAMOCHI | Growth Inhibition Assay | IC50=36.1198 μM | SANGER | |||
| SW48 | Growth Inhibition Assay | IC50=36.2474 μM | SANGER | |||
| Daoy | Growth Inhibition Assay | IC50=36.6538 μM | SANGER | |||
| TGBC24TKB | Growth Inhibition Assay | IC50=36.67 μM | SANGER | |||
| DU-4475 | Growth Inhibition Assay | IC50=36.9033 μM | SANGER | |||
| SW1417 | Growth Inhibition Assay | IC50=38.0552 μM | SANGER | |||
| EFO-21 | Growth Inhibition Assay | IC50=38.9349 μM | SANGER | |||
| MG-63 | Growth Inhibition Assay | IC50=39.3424 μM | SANGER | |||
| LC-2-ad | Growth Inhibition Assay | IC50=39.5512 μM | SANGER | |||
| NOMO-1 | Growth Inhibition Assay | IC50=39.8274 μM | SANGER | |||
| COLO-741 | Growth Inhibition Assay | IC50=40.1304 μM | SANGER | |||
| BxPC-3 | Growth Inhibition Assay | IC50=40.5686 μM | SANGER | |||
| HSC-2 | Growth Inhibition Assay | IC50=40.9113 μM | SANGER | |||
| UMC-11 | Growth Inhibition Assay | IC50=41.263 μM | SANGER | |||
| HCC1937 | Growth Inhibition Assay | IC50=42.7843 μM | SANGER | |||
| Calu-6 | Growth Inhibition Assay | IC50=43.2382 μM | SANGER | |||
| NCI-H1573 | Growth Inhibition Assay | IC50=43.3477 μM | SANGER | |||
| SK-N-AS | Growth Inhibition Assay | IC50=43.6019 μM | SANGER | |||
| PSN1 | Growth Inhibition Assay | IC50=45.2548 μM | SANGER | |||
| TE-11 | Growth Inhibition Assay | IC50=45.4842 μM | SANGER | |||
| NCI-H1155 | Growth Inhibition Assay | IC50=45.8967 μM | SANGER | |||
| KM12 | Growth Inhibition Assay | IC50=45.9076 μM | SANGER | |||
| RO82-W-1 | Growth Inhibition Assay | IC50=46.9822 μM | SANGER | |||
| SW1573 | Growth Inhibition Assay | IC50=47.3736 μM | SANGER | |||
| CAKI-1 | Growth Inhibition Assay | IC50=48.2845 μM | SANGER | |||
| U-118-MG | Growth Inhibition Assay | IC50=48.3702 μM | SANGER | |||
| KYSE-520 | Growth Inhibition Assay | IC50=48.4016 μM | SANGER | |||
| HT55 | Growth Inhibition Assay | IC50=49.1474 μM | SANGER | |||
| ChaGo-K-1 | Growth Inhibition Assay | IC50=49.4793 μM | SANGER | |||
| IA-LM | Growth Inhibition Assay | IC50=54.6322 μM | SANGER | |||
| UACC-62 | Growth Inhibition Assay | IC50=55.1046 μM | SANGER | |||
| MKN7 | Growth Inhibition Assay | IC50=56.0285 μM | SANGER | |||
| HPAF-II | Growth Inhibition Assay | IC50=56.4073 μM | SANGER | |||
| NTERA-S-cl-D1 | Growth Inhibition Assay | IC50=57.778 μM | SANGER | |||
| FTC-133 | Growth Inhibition Assay | IC50=58.0969 μM | SANGER | |||
| MHH-ES-1 | Growth Inhibition Assay | IC50=58.4814 μM | SANGER | |||
| JVM-2 | Growth Inhibition Assay | IC50=58.9506 μM | SANGER | |||
| TCCSUP | Growth Inhibition Assay | IC50=59.5279 μM | SANGER | |||
| COLO-824 | Growth Inhibition Assay | IC50=60.0719 μM | SANGER | |||
| 647-V | Growth Inhibition Assay | IC50=60.1347 μM | SANGER | |||
| HD-MY-Z | Growth Inhibition Assay | IC50=60.5294 μM | SANGER | |||
| LS-411N | Growth Inhibition Assay | IC50=61.3903 μM | SANGER | |||
| NCI-H596 | Growth Inhibition Assay | IC50=62.7496 μM | SANGER | |||
| C-33-A | Growth Inhibition Assay | IC50=64.0957 μM | SANGER | |||
| BHY | Growth Inhibition Assay | IC50=64.1245 μM | SANGER | |||
| KGN | Growth Inhibition Assay | IC50=64.5514 μM | SANGER | |||
| NCI-H1092 | Growth Inhibition Assay | IC50=65.0095 μM | SANGER | |||
| MZ1-PC | Growth Inhibition Assay | IC50=65.5649 μM | SANGER | |||
| LB831-BLC | Growth Inhibition Assay | IC50=65.8481 μM | SANGER | |||
| SW620 | Growth Inhibition Assay | IC50=66.2039 μM | SANGER | |||
| HuO-3N1 | Growth Inhibition Assay | IC50=68.3238 μM | SANGER | |||
| SK-HEP-1 | Growth Inhibition Assay | IC50=69.9486 μM | SANGER | |||
| LCLC-103H | Growth Inhibition Assay | IC50=70.6705 μM | SANGER | |||
| KYSE-70 | Growth Inhibition Assay | IC50=70.7835 μM | SANGER | |||
| Mewo | Growth Inhibition Assay | IC50=71.505 μM | SANGER | |||
| COLO-668 | Growth Inhibition Assay | IC50=71.8451 μM | SANGER | |||
| NCI-H522 | Growth Inhibition Assay | IC50=72.3413 μM | SANGER | |||
| NCI-H1437 | Growth Inhibition Assay | IC50=74.4048 μM | SANGER | |||
| U-266 | Growth Inhibition Assay | IC50=75.4516 μM | SANGER | |||
| MC116 | Growth Inhibition Assay | IC50=75.5708 μM | SANGER | |||
| PANC-10-05 | Growth Inhibition Assay | IC50=77.4243 μM | SANGER | |||
| KYSE-180 | Growth Inhibition Assay | IC50=77.5454 μM | SANGER | |||
| JAR | Growth Inhibition Assay | IC50=79.0546 μM | SANGER | |||
| CAL-62 | Growth Inhibition Assay | IC50=80.095 μM | SANGER | |||
| A3-KAW | Growth Inhibition Assay | IC50=80.2154 μM | SANGER | |||
| PANC-08-13 | Growth Inhibition Assay | IC50=81.1768 μM | SANGER | |||
| HSC-3 | Growth Inhibition Assay | IC50=83.3071 μM | SANGER | |||
| HTC-C3 | Growth Inhibition Assay | IC50=83.4702 μM | SANGER | |||
| KY821 | Growth Inhibition Assay | IC50=84.0892 μM | SANGER | |||
| DoTc2-4510 | Growth Inhibition Assay | IC50=84.2185 μM | SANGER | |||
| NCI-H1581 | Growth Inhibition Assay | IC50=85.4641 μM | SANGER | |||
| KARPAS-299 | Growth Inhibition Assay | IC50=86.1977 μM | SANGER | |||
| IST-MEL1 | Growth Inhibition Assay | IC50=86.8872 μM | SANGER | |||
| KP-N-YS | Growth Inhibition Assay | IC50=89.9028 μM | SANGER | |||
| KYSE-410 | Growth Inhibition Assay | IC50=91.4042 μM | SANGER | |||
| TE-10 | Growth Inhibition Assay | IC50=91.5611 μM | SANGER | |||
| SK-MEL-1 | Growth Inhibition Assay | IC50=92.9106 μM | SANGER | |||
| COLO-792 | Growth Inhibition Assay | IC50=95.2564 μM | SANGER | |||
| SCH | Growth Inhibition Assay | IC50=96.3877 μM | SANGER | |||
| NCI-H1792 | Growth Inhibition Assay | IC50=96.8992 μM | SANGER | |||
| NCI-H2029 | Growth Inhibition Assay | IC50=96.9566 μM | SANGER | |||
| SW684 | Growth Inhibition Assay | IC50=98.6654 μM | SANGER | |||
| NCI-H209 | Growth Inhibition Assay | IC50=100.121 μM | SANGER | |||
| HLE | Growth Inhibition Assay | IC50=105.282 μM | SANGER | |||
| GOTO | Growth Inhibition Assay | IC50=107.777 μM | SANGER | |||
| NCI-H1793 | Growth Inhibition Assay | IC50=109.28 μM | SANGER | |||
| D-392MG | Growth Inhibition Assay | IC50=117.398 μM | SANGER | |||
| SW1990 | Growth Inhibition Assay | IC50=120.951 μM | SANGER | |||
| ML-2 | Growth Inhibition Assay | IC50=121.676 μM | SANGER | |||
| SK-MEL-30 | Growth Inhibition Assay | IC50=123.244 μM | SANGER | |||
| NCI-H2452 | Growth Inhibition Assay | IC50=122.21 μM | SANGER | |||
| NCI-H1770 | Growth Inhibition Assay | IC50=125.514 μM | SANGER | |||
| SN12C | Growth Inhibition Assay | IC50=124.176 μM | SANGER | |||
| SF268 | Growth Inhibition Assay | IC50=126.158 μM | SANGER | |||
| COLO-679 | Growth Inhibition Assay | IC50=126.753 μM | SANGER | |||
| BALL-1 | Growth Inhibition Assay | IC50=126.23 μM | SANGER | |||
| A2780 | Growth Inhibition Assay | IC50=128.988 μM | SANGER | |||
| NCI-H1651 | Growth Inhibition Assay | IC50=131.243 μM | SANGER | |||
| NCI-H2087 | Growth Inhibition Assay | IC50=131.483 μM | SANGER | |||
| U-87-MG | Growth Inhibition Assay | IC50=133.604 μM | SANGER | |||
| LB2518-MEL | Growth Inhibition Assay | IC50=135.993 μM | SANGER | |||
| HCT-116 | Growth Inhibition Assay | IC50=137.217 μM | SANGER | |||
| Ca9-22 | Growth Inhibition Assay | IC50=139.833 μM | SANGER | |||
| COR-L88 | Growth Inhibition Assay | IC50=142.14 μM | SANGER | |||
| CP50-MEL-B | Growth Inhibition Assay | IC50=144.501 μM | SANGER | |||
| OVCAR-8 | Growth Inhibition Assay | IC50=145.636 μM | SANGER | |||
| SK-MEL-3 | Growth Inhibition Assay | IC50=147.878 μM | SANGER | |||
| GT3TKB | Growth Inhibition Assay | IC50=149.928 μM | SANGER | |||
| KYSE-450 | Growth Inhibition Assay | IC50=151.539 μM | SANGER | |||
| BEN | Growth Inhibition Assay | IC50=153.928 μM | SANGER | |||
| CAPAN-1 | Growth Inhibition Assay | IC50=153.064 μM | SANGER | |||
| NCI-H1304 | Growth Inhibition Assay | IC50=154.694 μM | SANGER | |||
| KU812 | Growth Inhibition Assay | IC50=158.674 μM | SANGER | |||
| Capan-2 | Growth Inhibition Assay | IC50=160.553 μM | SANGER | |||
| SAS | Growth Inhibition Assay | IC50=162.678 μM | SANGER | |||
| A673 | Growth Inhibition Assay | IC50=161.705 μM | SANGER | |||
| NY | Growth Inhibition Assay | IC50=165.314 μM | SANGER | |||
| HCE-4 | Growth Inhibition Assay | IC50=166.845 μM | SANGER | |||
| MDA-MB-231 | Growth Inhibition Assay | IC50=177.503 μM | SANGER | |||
| no-10 | Growth Inhibition Assay | IC50=178.134 μM | SANGER | |||
| MZ7-mel | Growth Inhibition Assay | IC50=178.467 μM | SANGER | |||
| NCI-H82 | Growth Inhibition Assay | IC50=180.165 μM | SANGER | |||
| CAL-72 | Growth Inhibition Assay | IC50=185.054 μM | SANGER | |||
| NCI-SNU-5 | Growth Inhibition Assay | IC50=186.84 μM | SANGER | |||
| OVCAR-4 | Growth Inhibition Assay | IC50=188.333 μM | SANGER | |||
| KYSE-150 | Growth Inhibition Assay | IC50=191.888 μM | SANGER | |||
| SCC-9 | Growth Inhibition Assay | IC50=191 μM | SANGER | |||
| HT-29 | Growth Inhibition Assay | IC50=201.212 μM | SANGER | |||
| COLO-678 | Growth Inhibition Assay | IC50=201.45 μM | SANGER | |||
| NCI-H650 | Growth Inhibition Assay | IC50=202.103 μM | SANGER | |||
| HuCCT1 | Growth Inhibition Assay | IC50=204.208 μM | SANGER | |||
| SW1116 | Growth Inhibition Assay | IC50=207.077 μM | SANGER | |||
| SW982 | Growth Inhibition Assay | IC50=207.948 μM | SANGER | |||
| DBTRG-05MG | Growth Inhibition Assay | IC50=207.909 μM | SANGER | |||
| RCM-1 | Growth Inhibition Assay | IC50=214.762 μM | SANGER | |||
| KNS-42 | Growth Inhibition Assay | IC50=216.574 μM | SANGER | |||
| COLO-320-HSR | Growth Inhibition Assay | IC50=216.125 μM | SANGER | |||
| C2BBe1 | Growth Inhibition Assay | IC50=231.905 μM | SANGER | |||
| CCRF-CEM | Growth Inhibition Assay | IC50=243.795 μM | SANGER | |||
| SH-4 | Growth Inhibition Assay | IC50=246.09 μM | SANGER | |||
| LS-1034 | Growth Inhibition Assay | IC50=246.266 μM | SANGER | |||
| NCI-H2347 | Growth Inhibition Assay | IC50=247.713 μM | SANGER | |||
| RPMI-8866 | Growth Inhibition Assay | IC50=249.27 μM | SANGER | |||
| GAK | Growth Inhibition Assay | IC50=253.002 μM | SANGER | |||
| NB6 | Growth Inhibition Assay | IC50=270.1 μM | SANGER | |||
| COLO-680N | Growth Inhibition Assay | IC50=272.527 μM | SANGER | |||
| RERF-LC-MS | Growth Inhibition Assay | IC50=276.007 μM | SANGER | |||
| TGBC11TKB | Growth Inhibition Assay | IC50=278.178 μM | SANGER | |||
| C8166 | Growth Inhibition Assay | IC50=278.506 μM | SANGER | |||
| HDLM-2 | Growth Inhibition Assay | IC50=294.409 μM | SANGER | |||
| IGR-1 | Growth Inhibition Assay | IC50=295.659 μM | SANGER | |||
| FADU | Growth Inhibition Assay | IC50=297.51 μM | SANGER | |||
| L-428 | Growth Inhibition Assay | IC50=297.616 μM | SANGER | |||
| LU-65 | Growth Inhibition Assay | IC50=304.32 μM | SANGER | |||
| NCI-H810 | Growth Inhibition Assay | IC50=310.57 μM | SANGER | |||
| HEL | Growth Inhibition Assay | IC50=309.983 μM | SANGER | |||
| C3A | Growth Inhibition Assay | IC50=311.802 μM | SANGER | |||
| KP-N-YN | Growth Inhibition Assay | IC50=341.123 μM | SANGER | |||
| NCI-H630 | Growth Inhibition Assay | IC50=332.294 μM | SANGER | |||
| MOLT-13 | Growth Inhibition Assay | IC50=342.326 μM | SANGER | |||
| NCI-H1993 | Growth Inhibition Assay | IC50=342.365 μM | SANGER | |||
| BE-13 | Growth Inhibition Assay | IC50=344.167 μM | SANGER | |||
| IST-SL1 | Growth Inhibition Assay | IC50=347.401 μM | SANGER | |||
| TE-9 | Growth Inhibition Assay | IC50=363.589 μM | SANGER | |||
| LU-135 | Growth Inhibition Assay | IC50=367.035 μM | SANGER | |||
| T84 | Growth Inhibition Assay | IC50=374.712 μM | SANGER | |||
| K-562 | Growth Inhibition Assay | IC50=383.36 μM | SANGER | |||
| SBC-5 | Growth Inhibition Assay | IC50=386.985 μM | SANGER | |||
| NB17 | Growth Inhibition Assay | IC50=392.596 μM | SANGER | |||
| NCI-H2052 | Growth Inhibition Assay | IC50=398.472 μM | SANGER | |||
| HCC38 | Growth Inhibition Assay | IC50=401.593 μM | SANGER | |||
| NCI-H69 | Growth Inhibition Assay | IC50=441.083 μM | SANGER | |||
| NCI-H526 | Growth Inhibition Assay | IC50=22.3895 μM | SANGER | |||
| NCI-H2122 | Growth Inhibition Assay | IC50=22.2432 μM | SANGER | |||
| KU-19-19 | Growth Inhibition Assay | IC50=22.1697 μM | SANGER | |||
| NCI-H661 | Growth Inhibition Assay | IC50=22.034 μM | SANGER | |||
| CGTH-W-1 | Growth Inhibition Assay | IC50=21.7166 μM | SANGER | |||
| KYSE-510 | Growth Inhibition Assay | IC50=21.6095 μM | SANGER | |||
| CW-2 | Growth Inhibition Assay | IC50=21.6069 μM | SANGER | |||
| LK-2 | Growth Inhibition Assay | IC50=21.5953 μM | SANGER | |||
| 22RV1 | Growth Inhibition Assay | IC50=21.5685 μM | SANGER | |||
| HT-3 | Growth Inhibition Assay | IC50=21.5631 μM | SANGER | |||
| LCLC-97TM1 | Growth Inhibition Assay | IC50=20.8134 μM | SANGER | |||
| NCI-H441 | Growth Inhibition Assay | IC50=20.7379 μM | SANGER | |||
| MIA-PaCa-2 | Growth Inhibition Assay | IC50=20.6883 μM | SANGER | |||
| HT-1080 | Growth Inhibition Assay | IC50=20.5497 μM | SANGER | |||
| NCI-H1355 | Growth Inhibition Assay | IC50=20.3374 μM | SANGER | |||
| Mo-T | Growth Inhibition Assay | IC50=20.1665 μM | SANGER | |||
| HL-60 | Growth Inhibition Assay | IC50=20.0941 μM | SANGER | |||
| KYSE-270 | Growth Inhibition Assay | IC50=20.0217 μM | SANGER | |||
| TE-8 | Growth Inhibition Assay | IC50=19.3024 μM | SANGER | |||
| 8305C | Growth Inhibition Assay | IC50=19.2286 μM | SANGER | |||
| GI-ME-N | Growth Inhibition Assay | IC50=19.1546 μM | SANGER | |||
| 8-MG-BA | Growth Inhibition Assay | IC50=19.0646 μM | SANGER | |||
| NCI-N87 | Growth Inhibition Assay | IC50=18.9008 μM | SANGER | |||
| A253 | Growth Inhibition Assay | IC50=18.7286 μM | SANGER | |||
| KM-H2 | Growth Inhibition Assay | IC50=18.5232 μM | SANGER | |||
| C32 | Growth Inhibition Assay | IC50=18.4727 μM | SANGER | |||
| 639-V | Growth Inhibition Assay | IC50=18.3354 μM | SANGER | |||
| CAL-85-1 | Growth Inhibition Assay | IC50=18.2357 μM | SANGER | |||
| EW-1 | Growth Inhibition Assay | IC50=18.1382 μM | SANGER | |||
| MHH-NB-11 | Growth Inhibition Assay | IC50=17.9673 μM | SANGER | |||
| M059J | Growth Inhibition Assay | IC50=17.703 μM | SANGER | |||
| KG-1 | Growth Inhibition Assay | IC50=17.6937 μM | SANGER | |||
| KOSC-2 | Growth Inhibition Assay | IC50=17.6757 μM | SANGER | |||
| UACC-257 | Growth Inhibition Assay | IC50=17.5512 μM | SANGER | |||
| NH-12 | Growth Inhibition Assay | IC50=17.3303 μM | SANGER | |||
| SW1783 | Growth Inhibition Assay | IC50=17.128 μM | SANGER | |||
| LOXIMVI | Growth Inhibition Assay | IC50=17.0707 μM | SANGER | |||
| BB65-RCC | Growth Inhibition Assay | IC50=17.0479 μM | SANGER | |||
| SK-MES-1 | Growth Inhibition Assay | IC50=16.8419 μM | SANGER | |||
| HCC1569 | Growth Inhibition Assay | IC50=16.8337 μM | SANGER | |||
| Detroit562 | Growth Inhibition Assay | IC50=16.7318 μM | SANGER | |||
| SK-LU-1 | Growth Inhibition Assay | IC50=16.6956 μM | SANGER | |||
| HuP-T3 | Growth Inhibition Assay | IC50=16.6373 μM | SANGER | |||
| MDA-MB-453 | Growth Inhibition Assay | IC50=16.1642 μM | SANGER | |||
| BFTC-905 | Growth Inhibition Assay | IC50=15.7694 μM | SANGER | |||
| SiHa | Growth Inhibition Assay | IC50=15.7594 μM | SANGER | |||
| NCI-H727 | Growth Inhibition Assay | IC50=15.4221 μM | SANGER | |||
| CAS-1 | Growth Inhibition Assay | IC50=15.4184 μM | SANGER | |||
| OE19 | Growth Inhibition Assay | IC50=15.1541 μM | SANGER | |||
| D-283MED | Growth Inhibition Assay | IC50=15.0111 μM | SANGER | |||
| PC-14 | Growth Inhibition Assay | IC50=14.9654 μM | SANGER | |||
| MS-1 | Growth Inhibition Assay | IC50=14.9611 μM | SANGER | |||
| NCI-H23 | Growth Inhibition Assay | IC50=14.7997 μM | SANGER | |||
| CAL-120 | Growth Inhibition Assay | IC50=14.7027 μM | SANGER | |||
| JEG-3 | Growth Inhibition Assay | IC50=14.6326 μM | SANGER | |||
| NCI-H2291 | Growth Inhibition Assay | IC50=14.5878 μM | SANGER | |||
| SW780 | Growth Inhibition Assay | IC50=14.5025 μM | SANGER | |||
| BPH-1 | Growth Inhibition Assay | IC50=14.1664 μM | SANGER | |||
| SCC-15 | Growth Inhibition Assay | IC50=13.9775 μM | SANGER | |||
| CHP-212 | Growth Inhibition Assay | IC50=13.9739 μM | SANGER | |||
| WM-115 | Growth Inhibition Assay | IC50=13.6483 μM | SANGER | |||
| CTV-1 | Growth Inhibition Assay | IC50=13.345 μM | SANGER | |||
| SJSA-1 | Growth Inhibition Assay | IC50=13.2327 μM | SANGER | |||
| HCC1187 | Growth Inhibition Assay | IC50=13.1912 μM | SANGER | |||
| TGBC1TKB | Growth Inhibition Assay | IC50=12.9115 μM | SANGER | |||
| Ca-Ski | Growth Inhibition Assay | IC50=12.9041 μM | SANGER | |||
| KYSE-140 | Growth Inhibition Assay | IC50=12.8595 μM | SANGER | |||
| KNS-81-FD | Growth Inhibition Assay | IC50=12.5869 μM | SANGER | |||
| GCIY | Growth Inhibition Assay | IC50=12.5209 μM | SANGER | |||
| BCPAP | Growth Inhibition Assay | IC50=12.4749 μM | SANGER | |||
| RH-1 | Growth Inhibition Assay | IC50=12.2184 μM | SANGER | |||
| RPMI-7951 | Growth Inhibition Assay | IC50=12.1854 μM | SANGER | |||
| BB49-HNC | Growth Inhibition Assay | IC50=12.1177 μM | SANGER | |||
| CAL-51 | Growth Inhibition Assay | IC50=12.0716 μM | SANGER | |||
| EKVX | Growth Inhibition Assay | IC50=12.0313 μM | SANGER | |||
| CFPAC-1 | Growth Inhibition Assay | IC50=11.9782 μM | SANGER | |||
| D-247MG | Growth Inhibition Assay | IC50=11.9663 μM | SANGER | |||
| GCT | Growth Inhibition Assay | IC50=11.8228 μM | SANGER | |||
| NCI-H1299 | Growth Inhibition Assay | IC50=11.8093 μM | SANGER | |||
| BB30-HNC | Growth Inhibition Assay | IC50=11.7982 μM | SANGER | |||
| MEG-01 | Growth Inhibition Assay | IC50=11.7509 μM | SANGER | |||
| A427 | Growth Inhibition Assay | IC50=11.7093 μM | SANGER | |||
| ONS-76 | Growth Inhibition Assay | IC50=11.636 μM | SANGER | |||
| PC-3 | Growth Inhibition Assay | IC50=11.5764 μM | SANGER | |||
| SW756 | Growth Inhibition Assay | IC50=11.5294 μM | SANGER | |||
| TK10 | Growth Inhibition Assay | IC50=11.5271 μM | SANGER | |||
| SW954 | Growth Inhibition Assay | IC50=11.4668 μM | SANGER | |||
| DEL | Growth Inhibition Assay | IC50=11.424 μM | SANGER | |||
| A388 | Growth Inhibition Assay | IC50=11.3897 μM | SANGER | |||
| SF539 | Growth Inhibition Assay | IC50=10.9041 μM | SANGER | |||
| no-11 | Growth Inhibition Assay | IC50=10.4353 μM | SANGER | |||
| A549 | Growth Inhibition Assay | IC50=10.3973 μM | SANGER | |||
| OVCAR-5 | Growth Inhibition Assay | IC50=10.2433 μM | SANGER | |||
| LAN-6 | Growth Inhibition Assay | IC50=10.2164 μM | SANGER | |||
| YKG-1 | Growth Inhibition Assay | IC50=10.2006 μM | SANGER | |||
| A101D | Growth Inhibition Assay | IC50=9.99974 μM | SANGER | |||
| MDA-MB-157 | Growth Inhibition Assay | IC50=9.92878 μM | SANGER | |||
| 5637 | Growth Inhibition Assay | IC50=9.84984 μM | SANGER | |||
| A431 | Growth Inhibition Assay | IC50=9.80238 μM | SANGER | |||
| U251 | Growth Inhibition Assay | IC50=9.65544 μM | SANGER | |||
| ACN | Growth Inhibition Assay | IC50=9.53277 μM | SANGER | |||
| SHP-77 | Growth Inhibition Assay | IC50=9.39935 μM | SANGER | |||
| LS-123 | Growth Inhibition Assay | IC50=9.31761 μM | SANGER | |||
| NBsusSR | Growth Inhibition Assay | IC50=9.27402 μM | SANGER | |||
| DSH1 | Growth Inhibition Assay | IC50=9.2087 μM | SANGER | |||
| HN | Growth Inhibition Assay | IC50=9.16628 μM | SANGER | |||
| EFO-27 | Growth Inhibition Assay | IC50=9.16412 μM | SANGER | |||
| 8505C | Growth Inhibition Assay | IC50=9.04232 μM | SANGER | |||
| NB10 | Growth Inhibition Assay | IC50=9.02224 μM | SANGER | |||
| HEC-1 | Growth Inhibition Assay | IC50=8.89866 μM | SANGER | |||
| ESS-1 | Growth Inhibition Assay | IC50=8.88704 μM | SANGER | |||
| D-502MG | Growth Inhibition Assay | IC50=8.78629 μM | SANGER | |||
| CAMA-1 | Growth Inhibition Assay | IC50=8.77146 μM | SANGER | |||
| SCC-4 | Growth Inhibition Assay | IC50=8.68219 μM | SANGER | |||
| LB771-HNC | Growth Inhibition Assay | IC50=8.64696 μM | SANGER | |||
| NCI-SNU-1 | Growth Inhibition Assay | IC50=8.64643 μM | SANGER | |||
| SKG-IIIa | Growth Inhibition Assay | IC50=8.63069 μM | SANGER | |||
| LB996-RCC | Growth Inhibition Assay | IC50=8.53257 μM | SANGER | |||
| SF126 | Growth Inhibition Assay | IC50=8.45936 μM | SANGER | |||
| HCC1954 | Growth Inhibition Assay | IC50=8.45104 μM | SANGER | |||
| T98G | Growth Inhibition Assay | IC50=8.18067 μM | SANGER | |||
| JVM-3 | Growth Inhibition Assay | IC50=8.15268 μM | SANGER | |||
| D-566MG | Growth Inhibition Assay | IC50=8.04429 μM | SANGER | |||
| TE-5 | Growth Inhibition Assay | IC50=7.79334 μM | SANGER | |||
| MSTO-211H | Growth Inhibition Assay | IC50=7.67336 μM | SANGER | |||
| CAL-33 | Growth Inhibition Assay | IC50=7.66233 μM | SANGER | |||
| GB-1 | Growth Inhibition Assay | IC50=7.54804 μM | SANGER | |||
| GP5d | Growth Inhibition Assay | IC50=7.48764 μM | SANGER | |||
| MC-IXC | Growth Inhibition Assay | IC50=7.48576 μM | SANGER | |||
| NCI-H28 | Growth Inhibition Assay | IC50=7.2924 μM | SANGER | |||
| LU-99A | Growth Inhibition Assay | IC50=7.14322 μM | SANGER | |||
| SW1463 | Growth Inhibition Assay | IC50=7.11168 μM | SANGER | |||
| RD | Growth Inhibition Assay | IC50=6.98284 μM | SANGER | |||
| AU565 | Growth Inhibition Assay | IC50=6.96957 μM | SANGER | |||
| TE-6 | Growth Inhibition Assay | IC50=6.93038 μM | SANGER | |||
| TE-12 | Growth Inhibition Assay | IC50=6.83817 μM | SANGER | |||
| A498 | Growth Inhibition Assay | IC50=6.81961 μM | SANGER | |||
| CHL-1 | Growth Inhibition Assay | IC50=6.80079 μM | SANGER | |||
| LN-405 | Growth Inhibition Assay | IC50=6.79672 μM | SANGER | |||
| NCI-H1693 | Growth Inhibition Assay | IC50=6.63604 μM | SANGER | |||
| A704 | Growth Inhibition Assay | IC50=6.6306 μM | SANGER | |||
| SNB75 | Growth Inhibition Assay | IC50=6.60143 μM | SANGER | |||
| D-263MG | Growth Inhibition Assay | IC50=6.45169 μM | SANGER | |||
| NB12 | Growth Inhibition Assay | IC50=6.39071 μM | SANGER | |||
| BFTC-909 | Growth Inhibition Assay | IC50=6.30345 μM | SANGER | |||
| BT-474 | Growth Inhibition Assay | IC50=6.233 μM | SANGER | |||
| EW-22 | Growth Inhibition Assay | IC50=6.19649 μM | SANGER | |||
| VMRC-RCZ | Growth Inhibition Assay | IC50=6.08773 μM | SANGER | |||
| SK-OV-3 | Growth Inhibition Assay | IC50=5.99816 μM | SANGER | |||
| Saos-2 | Growth Inhibition Assay | IC50=5.8653 μM | SANGER | |||
| Becker | Growth Inhibition Assay | IC50=5.86472 μM | SANGER | |||
| SF295 | Growth Inhibition Assay | IC50=5.80633 μM | SANGER | |||
| PFSK-1 | Growth Inhibition Assay | IC50=5.72732 μM | SANGER | |||
| RPMI-2650 | Growth Inhibition Assay | IC50=5.66199 μM | SANGER | |||
| SW872 | Growth Inhibition Assay | IC50=5.59428 μM | SANGER | |||
| CAL-27 | Growth Inhibition Assay | IC50=5.46339 μM | SANGER | |||
| MEL-HO | Growth Inhibition Assay | IC50=5.37336 μM | SANGER | |||
| BT-20 | Growth Inhibition Assay | IC50=5.21353 μM | SANGER | |||
| ETK-1 | Growth Inhibition Assay | IC50=5.21165 μM | SANGER | |||
| NCI-H446 | Growth Inhibition Assay | IC50=5.20009 μM | SANGER | |||
| SK-N-DZ | Growth Inhibition Assay | IC50=4.96142 μM | SANGER | |||
| 786-0 | Growth Inhibition Assay | IC50=4.94673 μM | SANGER | |||
| HO-1-N-1 | Growth Inhibition Assay | IC50=4.942 μM | SANGER | |||
| TI-73 | Growth Inhibition Assay | IC50=4.80609 μM | SANGER | |||
| CAL-39 | Growth Inhibition Assay | IC50=4.72146 μM | SANGER | |||
| KLE | Growth Inhibition Assay | IC50=4.70198 μM | SANGER | |||
| NB5 | Growth Inhibition Assay | IC50=4.53697 μM | SANGER | |||
| ATN-1 | Growth Inhibition Assay | IC50=4.44304 μM | SANGER | |||
| EW-11 | Growth Inhibition Assay | IC50=4.41838 μM | SANGER | |||
| HCE-T | Growth Inhibition Assay | IC50=4.41579 μM | SANGER | |||
| NCI-H292 | Growth Inhibition Assay | IC50=4.38146 μM | SANGER | |||
| EGI-1 | Growth Inhibition Assay | IC50=4.37778 μM | SANGER | |||
| NCI-H460 | Growth Inhibition Assay | IC50=4.26443 μM | SANGER | |||
| Calu-3 | Growth Inhibition Assay | IC50=4.24416 μM | SANGER | |||
| LAMA-84 | Growth Inhibition Assay | IC50=4.14191 μM | SANGER | |||
| TYK-nu | Growth Inhibition Assay | IC50=4.09534 μM | SANGER | |||
| SCC-25 | Growth Inhibition Assay | IC50=4.06566 μM | SANGER | |||
| MLMA | Growth Inhibition Assay | IC50=4.02966 μM | SANGER | |||
| TGW | Growth Inhibition Assay | IC50=4.02305 μM | SANGER | |||
| ECC10 | Growth Inhibition Assay | IC50=3.93622 μM | SANGER | |||
| LU-134-A | Growth Inhibition Assay | IC50=3.88428 μM | SANGER | |||
| RVH-421 | Growth Inhibition Assay | IC50=3.81788 μM | SANGER | |||
| P30-OHK | Growth Inhibition Assay | IC50=3.80976 μM | SANGER | |||
| MHH-PREB-1 | Growth Inhibition Assay | IC50=3.72038 μM | SANGER | |||
| G-402 | Growth Inhibition Assay | IC50=3.70711 μM | SANGER | |||
| SJRH30 | Growth Inhibition Assay | IC50=3.69122 μM | SANGER | |||
| KNS-62 | Growth Inhibition Assay | IC50=3.63338 μM | SANGER | |||
| AN3-CA | Growth Inhibition Assay | IC50=3.62456 μM | SANGER | |||
| DMS-114 | Growth Inhibition Assay | IC50=3.62278 μM | SANGER | |||
| RT-112 | Growth Inhibition Assay | IC50=3.52388 μM | SANGER | |||
| SW1710 | Growth Inhibition Assay | IC50=3.46678 μM | SANGER | |||
| H4 | Growth Inhibition Assay | IC50=3.45626 μM | SANGER | |||
| NCI-H1623 | Growth Inhibition Assay | IC50=3.41224 μM | SANGER | |||
| OVCAR-3 | Growth Inhibition Assay | IC50=3.40786 μM | SANGER | |||
| HCC2157 | Growth Inhibition Assay | IC50=3.38179 μM | SANGER | |||
| DOK | Growth Inhibition Assay | IC50=3.22859 μM | SANGER | |||
| EW-16 | Growth Inhibition Assay | IC50=3.21879 μM | SANGER | |||
| NCI-H747 | Growth Inhibition Assay | IC50=3.20694 μM | SANGER | |||
| EW-3 | Growth Inhibition Assay | IC50=3.19529 μM | SANGER | |||
| OS-RC-2 | Growth Inhibition Assay | IC50=3.1119 μM | SANGER | |||
| HuH-7 | Growth Inhibition Assay | IC50=3.09464 μM | SANGER | |||
| EoL-1- | Growth Inhibition Assay | IC50=3.07058 μM | SANGER | |||
| GR-ST | Growth Inhibition Assay | IC50=3.04611 μM | SANGER | |||
| NCI-H1048 | Growth Inhibition Assay | IC50=2.96865 μM | SANGER | |||
| SNU-423 | Growth Inhibition Assay | IC50=2.89242 μM | SANGER | |||
| MCF7 | Growth Inhibition Assay | IC50=2.86117 μM | SANGER | |||
| A204 | Growth Inhibition Assay | IC50=2.83872 μM | SANGER | |||
| MV-4-11 | Growth Inhibition Assay | IC50=2.75266 μM | SANGER | |||
| HCC1395 | Growth Inhibition Assay | IC50=2.75187 μM | SANGER | |||
| AGS | Growth Inhibition Assay | IC50=2.72137 μM | SANGER | |||
| RPMI-8226 | Growth Inhibition Assay | IC50=2.62953 μM | SANGER | |||
| RXF393 | Growth Inhibition Assay | IC50=2.60487 μM | SANGER | |||
| ES3 | Growth Inhibition Assay | IC50=2.49759 μM | SANGER | |||
| ES8 | Growth Inhibition Assay | IC50=2.49287 μM | SANGER | |||
| T-24 | Growth Inhibition Assay | IC50=2.47881 μM | SANGER | |||
| YH-13 | Growth Inhibition Assay | IC50=2.46153 μM | SANGER | |||
| EW-18 | Growth Inhibition Assay | IC50=2.41939 μM | SANGER | |||
| D-423MG | Growth Inhibition Assay | IC50=2.41044 μM | SANGER | |||
| VM-CUB-1 | Growth Inhibition Assay | IC50=2.39083 μM | SANGER | |||
| NB69 | Growth Inhibition Assay | IC50=2.38983 μM | SANGER | |||
| KS-1 | Growth Inhibition Assay | IC50=2.38191 μM | SANGER | |||
| LS-513 | Growth Inhibition Assay | IC50=2.33484 μM | SANGER | |||
| ABC-1 | Growth Inhibition Assay | IC50=2.33253 μM | SANGER | |||
| NCI-H2228 | Growth Inhibition Assay | IC50=2.31552 μM | SANGER | |||
| OAW-28 | Growth Inhibition Assay | IC50=2.29951 μM | SANGER | |||
| MN-60 | Growth Inhibition Assay | IC50=2.29923 μM | SANGER | |||
| LB1047-RCC | Growth Inhibition Assay | IC50=2.24317 μM | SANGER | |||
| GAMG | Growth Inhibition Assay | IC50=2.23845 μM | SANGER | |||
| NCI-H1395 | Growth Inhibition Assay | IC50=2.18091 μM | SANGER | |||
| RMG-I | Growth Inhibition Assay | IC50=2.16398 μM | SANGER | |||
| OC-314 | Growth Inhibition Assay | IC50=2.15086 μM | SANGER | |||
| Hs-578-T | Growth Inhibition Assay | IC50=2.11433 μM | SANGER | |||
| SW1088 | Growth Inhibition Assay | IC50=1.94606 μM | SANGER | |||
| SNU-387 | Growth Inhibition Assay | IC50=1.88406 μM | SANGER | |||
| RKO | Growth Inhibition Assay | IC50=1.87101 μM | SANGER | |||
| BV-173 | Growth Inhibition Assay | IC50=1.81074 μM | SANGER | |||
| COR-L105 | Growth Inhibition Assay | IC50=1.79737 μM | SANGER | |||
| OMC-1 | Growth Inhibition Assay | IC50=1.74677 μM | SANGER | |||
| CAL-54 | Growth Inhibition Assay | IC50=1.71242 μM | SANGER | |||
| HCC2218 | Growth Inhibition Assay | IC50=1.68225 μM | SANGER | |||
| ME-180 | Growth Inhibition Assay | IC50=1.56891 μM | SANGER | |||
| DMS-273 | Growth Inhibition Assay | IC50=1.51959 μM | SANGER | |||
| HOS | Growth Inhibition Assay | IC50=1.49558 μM | SANGER | |||
| QIMR-WIL | Growth Inhibition Assay | IC50=1.49116 μM | SANGER | |||
| 697 | Growth Inhibition Assay | IC50=1.37616 μM | SANGER | |||
| PA-1 | Growth Inhibition Assay | IC50=1.35265 μM | SANGER | |||
| MFM-223 | Growth Inhibition Assay | IC50=1.34461 μM | SANGER | |||
| Ramos-2G6-4C10 | Growth Inhibition Assay | IC50=1.33701 μM | SANGER | |||
| LoVo | Growth Inhibition Assay | IC50=1.32534 μM | SANGER | |||
| G-401 | Growth Inhibition Assay | IC50=1.29795 μM | SANGER | |||
| CTB-1 | Growth Inhibition Assay | IC50=1.2899 μM | SANGER | |||
| DOHH-2 | Growth Inhibition Assay | IC50=1.28203 μM | SANGER | |||
| ES1 | Growth Inhibition Assay | IC50=1.24065 μM | SANGER | |||
| COLO-684 | Growth Inhibition Assay | IC50=1.23725 μM | SANGER | |||
| EPLC-272H | Growth Inhibition Assay | IC50=1.17256 μM | SANGER | |||
| LXF-289 | Growth Inhibition Assay | IC50=1.17156 μM | SANGER | |||
| SK-NEP-1 | Growth Inhibition Assay | IC50=1.14485 μM | SANGER | |||
| LB2241-RCC | Growth Inhibition Assay | IC50=0.99734 μM | SANGER | |||
| NCI-H520 | Growth Inhibition Assay | IC50=0.98592 μM | SANGER | |||
| EM-2 | Growth Inhibition Assay | IC50=0.97939 μM | SANGER | |||
| MFE-280 | Growth Inhibition Assay | IC50=0.96465 μM | SANGER | |||
| HuO9 | Growth Inhibition Assay | IC50=0.92751 μM | SANGER | |||
| OAW-42 | Growth Inhibition Assay | IC50=0.8872 μM | SANGER | |||
| HOP-92 | Growth Inhibition Assay | IC50=0.87223 μM | SANGER | |||
| NKM-1 | Growth Inhibition Assay | IC50=0.86253 μM | SANGER | |||
| L-363 | Growth Inhibition Assay | IC50=0.83442 μM | SANGER | |||
| NB7 | Growth Inhibition Assay | IC50=0.82411 μM | SANGER | |||
| MOLT-4 | Growth Inhibition Assay | IC50=0.80582 μM | SANGER | |||
| J-RT3-T3-5 | Growth Inhibition Assay | IC50=0.74403 μM | SANGER | |||
| VA-ES-BJ | Growth Inhibition Assay | IC50=0.73025 μM | SANGER | |||
| OCUB-M | Growth Inhibition Assay | IC50=0.70966 μM | SANGER | |||
| DU-145 | Growth Inhibition Assay | IC50=0.64745 μM | SANGER | |||
| NOS-1 | Growth Inhibition Assay | IC50=0.63723 μM | SANGER | |||
| MDA-MB-415 | Growth Inhibition Assay | IC50=0.63626 μM | SANGER | |||
| HT | Growth Inhibition Assay | IC50=0.63239 μM | SANGER | |||
| HAL-01 | Growth Inhibition Assay | IC50=0.6213 μM | SANGER | |||
| LNCaP-Clone-FGC | Growth Inhibition Assay | IC50=0.61048 μM | SANGER | |||
| HCC70 | Growth Inhibition Assay | IC50=0.59827 μM | SANGER | |||
| KE-37 | Growth Inhibition Assay | IC50=0.5826 μM | SANGER | |||
| MDA-MB-361 | Growth Inhibition Assay | IC50=0.57761 μM | SANGER | |||
| HGC-27 | Growth Inhibition Assay | IC50=0.56783 μM | SANGER | |||
| IGROV-1 | Growth Inhibition Assay | IC50=0.55249 μM | SANGER | |||
| BHT-101 | Growth Inhibition Assay | IC50=0.52961 μM | SANGER | |||
| H-EMC-SS | Growth Inhibition Assay | IC50=0.49939 μM | SANGER | |||
| HCC1419 | Growth Inhibition Assay | IC50=0.48892 μM | SANGER | |||
| NCI-H1563 | Growth Inhibition Assay | IC50=0.48189 μM | SANGER | |||
| A4-Fuk | Growth Inhibition Assay | IC50=0.46868 μM | SANGER | |||
| SBC-1 | Growth Inhibition Assay | IC50=0.44035 μM | SANGER | |||
| EFM-19 | Growth Inhibition Assay | IC50=0.4401 μM | SANGER | |||
| H9 | Growth Inhibition Assay | IC50=0.38883 μM | SANGER | |||
| NCI-H720 | Growth Inhibition Assay | IC50=0.37679 μM | SANGER | |||
| KARPAS-45 | Growth Inhibition Assay | IC50=0.37321 μM | SANGER | |||
| RS4-11 | Growth Inhibition Assay | IC50=0.3461 μM | SANGER | |||
| ES5 | Growth Inhibition Assay | IC50=0.34455 μM | SANGER | |||
| MOLT-16 | Growth Inhibition Assay | IC50=0.3032 μM | SANGER | |||
| HH | Growth Inhibition Assay | IC50=0.30283 μM | SANGER | |||
| T47D | Growth Inhibition Assay | IC50=0.2825 μM | SANGER | |||
| AsPC-1 | Growth Inhibition Assay | IC50=0.22122 μM | SANGER | |||
| MDA-MB-175-VII | Growth Inhibition Assay | IC50=0.13738 μM | SANGER | |||
| P12-ICHIKAWA | Growth Inhibition Assay | IC50=0.1162 μM | SANGER | |||
| NEC8 | Growth Inhibition Assay | IC50=0.09651 μM | SANGER | |||
| HONE-1 | Function Assay | 10 μM | 48 h | DMSO | Induces cell cycle arrest at G1 | 25336925 |
| CNE-2 | Function Assay | 10 μM | 48 h | DMSO | Induces cell cycle arrest at G1 | 25336925 |
| HONE-1 | Growth Inhibition Assay | 10 μM | 96 h | DMSO | IC50=3.37 μM | 25336925 |
| SUNE-1 | Growth Inhibition Assay | 10 μM | 96 h | DMSO | IC50=0.52 μM | 25336925 |
| CNE-2 | Growth Inhibition Assay | 10 μM | 96 h | DMSO | IC50=4.53 μM | 25336925 |
| CNE-1 | Growth Inhibition Assay | 10 μM | 96 h | DMSO | IC50=2.96 μM | 25336925 |
| GEO | Growth Inhibition Assay | 500 nM | 72 h | DMSO | Inhibits cell growth | 24581231 |
| HepG2 cell | Apoptosis Assay | 20 μM | 24 h | DMSO | Induces cell apoptosis | 23797319 |
| HepG2 cell | Growth Inhibition Assay | 30 μM | 24 h | DMSO | Inhibits cell growth | 23797319 |
| HepG2 cell | Kinase Assay | 20 μM | 24 h | DMSO | Downregulates the phosphorylation of AKT | 23797319 |
| CEM-S | Function Assay | 4 μM | 4 h | DMSO | Increases the amount of cleaved LC5A/B, a well-established autophagy marker | 22614243 |
| CEM-R | Function Assay | 4 μM | 4 h | DMSO | Increases the amount of cleaved LC4A/B, a well-established autophagy marker | 22614243 |
| MOLT-4 | Function Assay | 4 μM | 4 h | DMSO | Increases the amount of cleaved LC3A/B, a well-established autophagy marker | 22614243 |
| MOLT-4 | Function Assay | 10 μM | 24 h | DMSO | Blocks cells in the G0/G1 phase of the cell cycle | 22614243 |
| CEM-S | Cytotoxic Assay | 10 μM | 48 h | DMSO | IC50=5.1 μM | 22614243 |
| CEM-R | Cytotoxic Assay | 10 μM | 48 h | DMSO | IC50=3.3 μM | 22614243 |
| MOLT-4 | Cytotoxic Assay | 10 μM | 48 h | DMSO | IC50=1.7 μM | 22614243 |
| HC11 | Function Assay | 10 μM | 24 h | DMSO | Inhibits β-casein and ADRP synthesis | 22426621 |
| T98G | Apoptosis Assay | 0.5 μM | 60 h | DMSO | Augments apoptogenic effects of | 22057914 |
| TAD2 | Growth Inhibition Assay | 1000 μM | 5 d | DMSO | IC50>1000 μM | 21289267 |
| LN229 | Apoptosis Assay | 0.5 μM | 60 h | DMSO | Augments apoptogenic effects of | 22057914 |
| WRO | Growth Inhibition Assay | 1000 μM | 5 d | DMSO | IC50>1000 μM | 21289267 |
| SW1736 | Growth Inhibition Assay | 100 μM | 5 d | DMSO | IC50=47.56 μM | 21289267 |
| KAT18 | Growth Inhibition Assay | 3 μM | 5 d | DMSO | IC50=4.62 μM | 21289267 |
| Hth74 | Growth Inhibition Assay | 3 μM | 5 d | DMSO | IC50=2.19 μM | 21289267 |
| TPC1 cells harbored RET/PTC1 rearrangement | Growth Inhibition Assay | 3 μM | 5 d | DMSO | IC50=0.59 μM | 21289267 |
| Hth7 cells harbored NRAS (Q61R+/−) | Growth Inhibition Assay | 3 μM | 5 d | DMSO | IC50=4.5 μM | 21289267 |
| C643 cells harbored HRAS (G13R+/−) | Growth Inhibition Assay | 3 μM | 5 d | DMSO | IC50=0.27 μM | 21289267 |
| FTC133 cells harbored PTEN (allele deletion and R130+) | Growth Inhibition Assay | 3 μM | 5 d | DMSO | IC50=0.18 μM | 21289267 |
| K1 cells harbored PIK3CA (E542K+/+) | Growth Inhibition Assay | 3 μM | 5 d | DMSO | IC50=0.52 μM | 21289267 |
| OCUT1 cells harbored PIK3CA (H1047R+/+) | Growth Inhibition Assay | 3 μM | 5 d | DMSO | IC50=0.14 μM | 21289267 |
| Sk-Hep1 | Cytotoxic Assay | 10 μM | 24 h | DMSO | Sensitizes resistant cells to the cytotoxic effect of | 21205925 |
| HepG2 | Cytotoxic Assay | 10 μM | 24 h | DMSO | Sensitizes resistant cells to the cytotoxic effect of | 21205925 |
| A431 | Kinase Assay | 5 μM | 5 h | DMSO | Suppresses the signaling of Akt and Erk | 20571069 |
| NCI-H292 | Cytotoxic Assay | 3 μM | 72 h | DMSO | Inhibition of cell proliferation | 20571069 |
| HeLa | Function assay | 1 h | IC50 = 0.0228 μM | 29100733 | ||
| NCI-H460 | Growth inhibition assay | 72 h | IC50 = 5.4 μM | 24900862 | ||
| HCT116 | Growth inhibition assay | 72 h | IC50 = 7.5 μM | 24900862 | ||
| A673 | Function assay | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for A673 cells | 29435139 | |||
| DAOY | Function assay | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for DAOY cells | 29435139 | |||
| Saos-2 | Function assay | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Saos-2 cells | 29435139 | |||
| BT-37 | Function assay | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-37 cells | 29435139 | |||
| RD | Function assay | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for RD cells | 29435139 | |||
| SK-N-SH | Function assay | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-SH cells | 29435139 | |||
| BT-12 | Function assay | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-12 cells | 29435139 | |||
| MG 63 (6-TG R) | Function assay | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for MG 63 (6-TG R) cells | 29435139 | |||
| NB1643 | Function assay | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB1643 cells | 29435139 | |||
| OHS-50 | Function assay | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for OHS-50 cells | 29435139 | |||
| Rh41 | Function assay | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh41 cells | 29435139 | |||
| Rh30 | Function assay | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh30 cells | 29435139 | |||
| SJ-GBM2 | Function assay | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SJ-GBM2 cells | 29435139 | |||
| SK-N-MC | Function assay | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-MC cells | 29435139 | |||
| NB-EBc1 | Function assay | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB-EBc1 cells | 29435139 | |||
| LAN-5 | Function assay | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for LAN-5 cells | 29435139 | |||
| Rh18 | Function assay | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh18 cells | 29435139 | |||
| Click to View More Cell Line Experimental Data | ||||||
Biological Activity
| Description | MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM in cell-free assays, respectively; no inhibitory activities against 250 other protein kinases observed. MK-2206 2HCl induces autophagy and apoptosis in cancer cells. Phase 2. | ||||||
|---|---|---|---|---|---|---|---|
| Features | The first allosteric small molecule inhibitor of Akt to enter clinical development. | ||||||
| Targets |
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| In vitro | ||||
| In vitro | MK-2206 is an allosteric inhibitor and is activated by the pleckstrin homology domain. MK-2206 inhibits auto-phosphorylation of both Akt T308 and S473. MK-2206 also prevents Akt-mediated phosphorylation of downstream signaling molecules, including TSC2, PRAS40 and ribosomal S6 proteins. [1] MK-2206 inhibits Ras wild-type (WT) cell lines (A431, HCC827, and NCI-H292) more potently when compared to Ras-mutant cell lines (NCI-H358, NCI-H23, NCI-H1299, and Calu-6). MK-2206 also shows synergistic responses in combination with cytotoxic agents in lung NCI-H460 or ovarian A2780 tumor cells. [2] MK-2206 or siRNA-mediated Akt inhibition strongly activates autophagy in human glioma cells. However, eukaryotic elongation factor-2 (eEF-2) silencing suppresses MK-2206-induced-autophagy, with a promotion of apoptotic cell death. [3] |
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| Kinase Assay | Akt kinases assay | |||
| Akt kinases are assayed by a GSK-derived biotinylated peptide substrate. The extent of peptide phosphorylation is determined by Homogeneous Time Resolved Fluorescence (HTRF) using a lanthanide chelate (Lance)-coupled monoclonal antibody specific for the phosphopeptide in combination with a streptavidin-linked allophycocyanin (SA-APC) fluorophore which will bind to the biotin moiety on the peptide. When the Lance and APC are in proximity, a non-radiative energy transfer takes place from the Lance to the APC, followed by emission of light from APC at 655 nm. 10X assay buffer: 500 mM HEPES, pH7.5, 1% PEG, 16.6 mM EDTA, 1 mM EGTA, 1% BSA, 20 mM 9-glycerol phosphate; Quench buffer 50 mM HEPES pH 7.3, 16.6 mM EDTA, 0.1% BSA, 0.1% Triton X-100, 0.17 nM labeled monoclonal antibody, 0.0067 mg/mL SA-APC; ATP/MgCl2 working solution: 1X Assay buffer, 1 mM DTT, 1X PIC, 5% glycerol, active Akt; Peptide working solution: 1X Assay buffer, 1 mM DTT, 1X PIC, 5% glycerol, 2 TM GSK biotinylated peptide. The reaction is assembled by adding 16 µL of ATP/MgCl2 working solution to the appropriate wells. MK-2206 or vehicle (1.0 µL) is added followed by 10 µL of peptide working solution. The reaction is started by adding 13 μL of the enzyme working solution and mixing. The reaction is allowed to proceed for 50 min and then stopped by the addition of 60 µL HTRF quench buffer. The stopped reactions are incubated at room temperature for at least 30 min and then read in the instrument. | ||||
| Cell Research | Cell lines | A431, HCC827, NCI-H292, NCI-H358, NCI-H23, NCI-H1299, Calu-6 and NCI-H460 cells | ||
| Concentrations | 0, 0.3, 1 and 3 μM | |||
| Incubation Time | 72 or 96 hours | |||
| Method | MK-2206 is dissolved in DMSO as a stock solution and diluted by culture media before use. Cells are seeded at a density of 2-3 × 103 in 96-well plates and incubated for 24 hours. Then MK-2206 (0, 0.3, 1 and 3 μM) is added to the cells. Cell proliferation is determined after 72 or 96 hours. |
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| Experimental Result Images | Methods | Biomarkers | Images | PMID |
| Western blot | p-AKT(T308) / p-AKT(S473) / pGSK3β(S9) / pFOXO1 / pPRAS(T246) / pBAD / pS6K(T389) / p4E-BP1 |
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22932669 | |
| Growth inhibition assay | Cell viability |
|
24665203 | |
| Immunofluorescence | LC3 CFTR/LC3 HMGA2 |
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24490764 | |
| ELISA | VEGFA |
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29449553 | |
| In Vivo | ||
| In vivo | MK-2206 shows 60% TGI and inhibits more than 70 % of phospho-Akt1/2 (T308 and S473) in A2780 ovarian cancer xenografts at a dose of 240 mg/kg. [1] MK-2206 exhibits significant antitumor activity in NCI-H292 xenograft in combination. [2] |
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|---|---|---|
| Animal Research | Animal Models | SK-OV-3, NCI-H292, HCC70, PC-3, and NCI-H460 models in male CD1-nude mice |
| Dosages | 120 mg/kg | |
| Administration | Orally administered | |
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT01480154 | Active not recruiting | Advanced Malignant Solid Neoplasm|Stage III Cutaneous Melanoma AJCC v7|Stage III Prostate Cancer AJCC v7|Stage III Renal Cell Cancer AJCC v7|Stage IIIA Cutaneous Melanoma AJCC v7|Stage IIIB Cutaneous Melanoma AJCC v7|Stage IIIC Cutaneous Melanoma AJCC v7|Stage IV Cutaneous Melanoma AJCC v6 and v7|Stage IV Prostate Cancer AJCC v7|Stage IV Renal Cell Cancer AJCC v7 |
National Cancer Institute (NCI) |
November 23 2011 | Phase 1 |
| NCT01466868 | Terminated | Diffuse Large B Cell Lymphoma |
Centre Leon Berard|National Cancer Institute France |
November 2011 | Phase 2 |
Chemical Information & Solubility
| Molecular Weight | 480.39 | Formula | C25H21N5O.2HCl |
| CAS No. | 1032350-13-2 | SDF | Download MK-2206 2HCl SDF |
| Smiles | C1CC(C1)(C2=CC=C(C=C2)C3=C(C=C4C(=N3)C=CN5C4=NNC5=O)C6=CC=CC=C6)N.Cl.Cl | ||
| Storage (From the date of receipt) | |||
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In vitro |
DMSO : 96 mg/mL ( (199.83 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.) Water : 96 mg/mL Ethanol : Insoluble |
Molecular Weight Calculator |
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In vivo Add solvents to the product individually and in order. |
In vivo Formulation Calculator |
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Tech Support
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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Frequently Asked Questions
Question 1:
What is your recommendation for preparing the solution and how would you deliver it to the mice (i.p. or gavage)?
Answer:
You can resuspend MK-2206 in 15% Captisol at up to 17mg/ml. It's a suspension and is for oral gavage use only.
Question 2:
I would want to know if MK-2206 could cross the blood brain barrier?
Answer:
MK-2206 can cross BBB based on the following reference: https://clinicaltrials.gov/ct2/show/NCT01249105.
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